Subcortical brain structure and suicidal behaviour in major depressive disorder: A meta-analysis from the ENIGMA-MDD working group

M E Rentería; L Schmaal; D P Hibar; B Couvy-Duchesne; L T Strike; N T Mills; G I De Zubicaray; K L McMahon; S E Medland; N A Gillespie; S N Hatton; Jim Lagopoulos; D J Veltman; N Van Der Wee; T G M Van Erp; K Wittfeld; H J Grabe; A Block; K Hegenscheid; H Völzke; I M Veer; H Walter; K Schnell; E Schramm; C Normann; D Schoepf; C Konrad; B Zurowski; B R Godlewska; P J Cowen; B W J H Penninx; N Jahanshad; P M Thompson; M J Wright; N G Martin; H Christensen; I B Hickie; ENIGMA-Major Depressive Disorder Working Group

doi:10.1038/tp.2017.84

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Subcortical brain structure and suicidal behaviour in major depressive disorder: A meta-analysis from the ENIGMA-MDD working group

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Subcortical brain structure and suicidal behaviour in major depressive disorder: A meta-analysis from the ENIGMA-MDD working group

M E Rentería, L Schmaal, D P Hibar, B Couvy-Duchesne, L T Strike, N T Mills, G I De Zubicaray, K L McMahon, S E Medland, N A Gillespie, …

Translational Psychiatry, Vol.7, pp.1-7

2017

DOI: https://doi.org/10.1038/tp.2017.84

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Abstract

The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n = 3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts. We compared mean subcortical grey matter volumes, lateral ventricle volumes and total intracranial volume (ICV) in MDD patients with suicidal symptoms (N = 451) vs healthy controls (N = 1996) or MDD patients with no suicidal symptoms (N = 650). MDD patients reporting suicidal plans or attempts showed a smaller ICV (P = 4.12 × 10 - 3) or a 2.87% smaller volume compared with controls (Cohen's d = - 0.284). In addition, we observed a nonsignificant trend in which MDD cases with suicidal symptoms had smaller subcortical volumes and larger ventricular volumes compared with controls. Finally, no significant differences (P = 0.28-0.97) were found between MDD patients with and those without suicidal symptoms for any of the brain volume measures. This is by far the largest neuroimaging meta-analysis of suicidal behaviour in MDD to date. Our results did not replicate previous reports of association between subcortical brain structure and suicidality and highlight the need for collecting better-powered imaging samples and using improved suicidality assessment instruments.

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Title: Subcortical brain structure and suicidal behaviour in major depressive disorder: A meta-analysis from the ENIGMA-MDD working group
Authors: M E Rentería (Author)
L Schmaal (Author)
D P Hibar (Author)
B Couvy-Duchesne (Author)
L T Strike (Author)
N T Mills (Author)
G I De Zubicaray (Author)
K L McMahon (Author)
S E Medland (Author)
N A Gillespie (Author)
S N Hatton (Author)
Jim Lagopoulos (Author) - University of Sydney
D J Veltman (Author)
N Van Der Wee (Author)
T G M Van Erp (Author)
K Wittfeld (Author)
H J Grabe (Author)
A Block (Author)
K Hegenscheid (Author)
H Völzke (Author)
I M Veer (Author)
H Walter (Author)
K Schnell (Author)
E Schramm (Author)
C Normann (Author)
D Schoepf (Author)
C Konrad (Author)
B Zurowski (Author)
B R Godlewska (Author)
P J Cowen (Author)
B W J H Penninx (Author)
N Jahanshad (Author)
P M Thompson (Author)
M J Wright (Author)
N G Martin (Author)
H Christensen (Author)
I B Hickie (Author)
ENIGMA-Major Depressive Disorder Working Group (Author)
Publication details: Translational Psychiatry, Vol.7, pp.1-7
Publisher: Nature Publishing Group
Date published: 2017
DOI: 10.1038/tp.2017.84
ISSN: 2158-3188
Copyright note: Copyright © The Author(s) 2017. This work is licensed under a Creative Commons Attribution- NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451006802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

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