Subcortical Volume Correlates of Psychological Distress in Early Adolescence

Kathryn Broadhouse; Amanda L Boyes; Natalie Winks; Tayla Dokonal; Larisa McLoughlin; Marcella Parker; Denise Beaudequin; Gabrielle Simcock; Jim Lagopoulos; Daniel F Hermens

doi:10.1159/000502339

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Subcortical Volume Correlates of Psychological Distress in Early Adolescence

Journal article

Peer reviewed

Subcortical Volume Correlates of Psychological Distress in Early Adolescence

Kathryn Broadhouse, Amanda L Boyes, Natalie Winks, Tayla Dokonal, Larisa McLoughlin, Marcella Parker, Denise Beaudequin, Gabrielle Simcock, Jim Lagopoulos and Daniel F Hermens

Developmental Neuroscience, Vol.41(3-4), pp.193-202

2020

DOI: https://doi.org/10.1159/000502339

Appears in Thompson Institute Research Collection

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Abstract

mental health disorders

early adolescence

hippocampal subfields

amygdala nuclei

neuroimaging

Youth mental health

Longitudinal Adolescent Brain Study

Thompson Institute Special Collection

UniSC Diversity Area - Disability and Inclusion

UniSC Diversity Area - Life Stages

The hippocampus and amygdala have justifiably been the focus of much mental health research due to their putative roles in top-down processing control of emotion, fear, and anxiety. However, understanding the causal relationship between these regions and mental illness has been limited as current literature is lacking in the observation of neuro-structural changes preceding first episodes. Here, we report whole and sub-structural hippocampal and amygdala volume correlates of psychological distress in early adolescence. Automated hippocampal subfield and amygdala nuclei segmentation was carried out in 32 participants (12-13 years old) recruited for the Longitudinal Adolescent Brain Study (LABS) who had psychological distress scores measured by the Kessler-10. Partial correlation analyses revealed significant negative association between left whole amygdala volume and psychological distress. Sub-structure analysis revealed that smaller left hippocampal CA1 volume and left basal and accessory basal amygdala nuclei volumes were all significantly associated with higher levels of psychological distress. Four-month follow-up analysis also revealed an association between change in K10 and CA1 volume suggesting a continued relationship between this hippocampal substructure and psychological distress. Grey matter volume of subcortical sub-structures involved within the hippocampal-basolateral amygdala-prefrontal cortex loop are highly correlated and are significantly reduced in adolescents with higher levels of psychological distress, indicating these nuclei and subfields play an important role in the emergence of mental illness.

Details

Title: Subcortical Volume Correlates of Psychological Distress in Early Adolescence
Authors: Kathryn Broadhouse (Author) - University of the Sunshine Coast
Amanda L Boyes (Author) - University of the Sunshine Coast
Natalie Winks (Author) - University of the Sunshine Coast
Tayla Dokonal (Author) - University of the Sunshine Coast
Larisa McLoughlin (Author) - University of the Sunshine Coast
Marcella Parker (Author) - University of the Sunshine Coast
Denise Beaudequin (Author) - University of the Sunshine Coast
Gabrielle Simcock (Author) - University of the Sunshine Coast
Jim Lagopoulos (Author) - University of the Sunshine Coast
Daniel F Hermens (Author) - University of the Sunshine Coast
Publication details: Developmental Neuroscience, Vol.41(3-4), pp.193-202
Publisher: S. Karger AG
Date published: 2020
DOI: 10.1159/000502339
ISSN: 0378-5866
Organisation Unit: School of Science and Engineering - Legacy; School of Health - Nursing; School of Health and Sport Sciences - Legacy; Thompson Institute
Language: English
Record Identifier: 99451137402621
Output Type: Journal article

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