Subclinical Psychotic Experiences in Healthy Young Adults: Associations with Stress and Genetic Predisposition

Dagmar Bruenig; Melanie J White; Ross Young; Joanne Voisey

doi:10.1089/gtmb.2014.0111

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Subclinical Psychotic Experiences in Healthy Young Adults: Associations with Stress and Genetic Predisposition

Journal article

Open access

Peer reviewed

Subclinical Psychotic Experiences in Healthy Young Adults: Associations with Stress and Genetic Predisposition

Dagmar Bruenig, Melanie J White, Ross Young and Joanne Voisey

Genetic Testing and Molecular Biomarkers, Vol.18(10), pp.683-689

2014

DOI: https://doi.org/10.1089/gtmb.2014.0111

PMID: 25184405

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Abstract

subclinical psychotic experiences

stress

COMT

DRD2

AKT1

SLC39A8

HLA region

Stress has been identified as a common trigger for psychosis. Dopamine pathways are suggested to be affected by chronic and severe stress and to play an important role in psychosis. This pilot study investigates the potential relationship of stress and psychosis in subclinical psychotic experiences. It was hypothesised that single nucleotide polymorphisms (SNPs) previously found to be associated with psychiatric disorders would be associated with both stress and subclinical psychotic experiences. University students (N = 182) were genotyped for 17 SNPs across 11 genes. Higher stress reporting was associated with rs4680 COMT, rs13211507 HLA Region, and rs13107325 SLC39A8. Reports of higher subclinical psychotic experiences were associated with DRD2 SNPs rs17601612 and rs658986 and an AKT1 SNP rs2494732. Replication studies are recommended to further pursue this line of research for identification of markers of psychosis for early diagnosis and intervention.

Details

Title: Subclinical Psychotic Experiences in Healthy Young Adults: Associations with Stress and Genetic Predisposition
Authors: Dagmar Bruenig (Author) - Queensland University of Technology
Melanie J White (Author) - Queensland University of Technology
Ross Young (Author) - Queensland University of Technology
Joanne Voisey (Author) - Queensland University of Technology
Publication details: Genetic Testing and Molecular Biomarkers, Vol.18(10), pp.683-689
Publisher: Mary Ann Liebert, Inc. Publishers
Date published: 2014
DOI: 10.1089/gtmb.2014.0111
ISSN: 1945-0257; 1945-0265
PMID: 25184405
Copyright note: Copyright (c) 2014. Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/gtmb.2014.0111
Organisation Unit: University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
Language: English
Record Identifier: 99551607802621
Output Type: Journal article

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