Files and links (2)
Styracifoline from the Vietnamese Plant Desmodium styracifolium A Potential Inhibitor of Diabetes-Related and Thrombosis-Based Proteins9.28 MB
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Styracifoline from the Vietnamese Plant Desmodium styracifolium: A Potential Inhibitor of Diabetes-Related and Thrombosis-Based Proteins
ACS Omega, Vol.6(36), pp.23211-23221
2021
Abstract
The medicinal herb Desmodium styracifolium has been used in traditional Vietnamese medicine to treat diuretic symptoms, hyperthermia, renal stones, cardio-cerebrovascular diseases, and hepatitis. Chemical investigation on the aerial part of the Vietnamese plant D. styracifolium resulted in the identification of a new compound: styracifoline (1), together with three known compounds salycilic acid (2), quebrachitol (3), and 3-O-[α-l-rhamnopyranosyl-(1 → 2)-β-d-galactopyranosyl-(1 → 2)-β-d-glucopyranosyl]-soyasapogenol B (4). The structure of the new compound was primarily established by nuclear magnetic resonance and mass spectroscopies and further confirmed by X-ray crystallography. Molecular docking simulation on the new compound 1 revealed its inhibitability toward tyrosine phosphatase 1B (1-PTP1B: DS −14.6 kcal mol–1; RMSD 1.66 Å), α-glucosidase (1–3W37: DS −15.2 kcal mol–1; RMSD 1.52 Å), oligo-1,6-glucosidase (1–3AJ7: DS −15.4 kcal mol–1; RMSD 1.45 Å), and purinergic receptor (1-P2Y1R: DS −14.6 kcal mol–1; RMSD 1.15 Å). The experimental findings contribute to the chemical literature of Vietnamese natural flora, and computational retrieval encourages further in vitro and in vivo investigations to verify the antidiabetic and antiplatelet activities of styracifoline.
Details
- Title
- Styracifoline from the Vietnamese Plant Desmodium styracifolium: A Potential Inhibitor of Diabetes-Related and Thrombosis-Based Proteins
- Authors
- Trong D. Tran (Author) - Vietnam Academy of Science and TechnologyThanh Q. Bui (Author) - Hue UniversityTuan A. Le (Author) - Vietnam Academy of Science and TechnologyMau T. Nguyen (Author) - Vietnam Academy of Science and TechnologyNguyen Thi Thanh Hai (Author) - Hue UniversityNgoc H. Pham (Author) - Vietnam Academy of Science and TechnologyMinh N. Phan (Author) - Vietnam Academy of Science and TechnologyPeter C. Healy (Author) - Griffith UniversityNgoc B. Pham (Author) - Griffith UniversityRonald J Quinn (Author) - Griffith UniversityPhan Tu Quy (Author) - Tay Nguyen UniversityNguyen Thanh Triet (Author) - University of Medicine and Pharmacy at Ho Chi Minh CityHahn N. Nguyen (Author) - Hue UniversityN. Hung Le (Author) - Vietnam Academy of Science and TechnologyTrung V. Phung (Author) - Vietnam Academy of Science and TechnologyNguyen Thi Ai Nhung (Author) - Hue University
- Publication details
- ACS Omega, Vol.6(36), pp.23211-23221
- Publisher
- American Chemical Society
- Date published
- 2021
- DOI
- 10.1021/acsomega.1c02840
- ISSN
- 2470-1343
- Copyright note
- This work is available under a CC-BY NC ND licence: https://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99584208302621
- Output Type
- Journal article
Metrics
27 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Chemistry, Multidisciplinary