Structure determination of pentacyclic pyridoacridine alkaloids from the australian marine organisms ancorina geodides and cnemidocarpa stolonifera

Trong D Tran; N B Pham; R J Quinn

doi:10.1002/ejoc.201402372

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Structure determination of pentacyclic pyridoacridine alkaloids from the australian marine organisms ancorina geodides and cnemidocarpa stolonifera

Journal article

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Structure determination of pentacyclic pyridoacridine alkaloids from the australian marine organisms ancorina geodides and cnemidocarpa stolonifera

Trong D Tran, N B Pham and R J Quinn

European Journal of Organic Chemistry, Vol.2014(22), pp.4805-4816

2014

DOI: https://doi.org/10.1002/ejoc.201402372

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Abstract

alkaloids

cytotoxicity

density functional calculations

natural products

structure elucidation

Chemical investigation of two marine samples A. geodides and C. stolonifera led to the isolation of six pentacyclic pyridoacridine alkaloids, in which two compounds, ancorine A and cnemidine A, are new pyridoacridines. Their structures were determined by NMR spectroscopic analysis supported by quantum mechanical calculations of 13C NMR chemical shifts. This is the first study demonstrating that the pyridoacridine structure class can be assigned on the basis of quantum mechanical calculations. The isolated pyridoacridine alkaloids showed selective cytotoxicity against human prostate cancer cells (PC3) compared with human neonatal foreskin fibroblast noncancer cells (NFF). © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Details

Title: Structure determination of pentacyclic pyridoacridine alkaloids from the australian marine organisms ancorina geodides and cnemidocarpa stolonifera
Authors: Trong D Tran (Author) - Griffith University
N B Pham (Author) - Griffith University
R J Quinn (Author) - Griffith University
Publication details: European Journal of Organic Chemistry, Vol.2014(22), pp.4805-4816
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
DOI: 10.1002/ejoc.201402372
ISSN: 1434-193X
Organisation Unit: Centre for Bioinnovation; School of Science, Technology and Engineering; University of the Sunshine Coast, Queensland; School of Science and Engineering - Legacy
Language: English
Record Identifier: 99451166402621
Output Type: Journal article

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