Structure and functions of inhibitory and excitatory glycine receptors

H Betz; J Kuhse; V Schmieden; B Laube; J Kirsch; Robert J Harvey

doi:10.1111/j.1749-6632.1999.tb11343.x

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Structure and functions of inhibitory and excitatory glycine receptors

Journal article

Peer reviewed

Structure and functions of inhibitory and excitatory glycine receptors

H Betz, J Kuhse, V Schmieden, B Laube, J Kirsch and Robert J Harvey

Annals of the New York Academy of Sciences, Vol.868, pp.667-676

1999

DOI: https://doi.org/10.1111/j.1749-6632.1999.tb11343.x

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Abstract

chloride channel

excitatory amino acid receptor

gephyrin

glycine receptor

isoprotein

receptor subunit

zinc ion

The strychnine-sensitive glycine receptor (GlyR) is a pentameric chloride channel protein that exists in several developmentally and regionally regulated isoforms in the CNS. These result from the differential expression of four genes encoding different variants (α1-α4) of the ligand-binding subunit of the GlyR. Their assembly with the structural β subunit is governed by 'assembly cassettes' within the extracellular domains of these proteins and creates chloride channels of distinct conductance properties. GlyR gating is potentiated by Zn2+, a metal ion co-released with different neurotransmitters. Site-directed mutagenesis has unraveled major determinants of agonist binding and Zn(Z+) potentiation. During development, glycine receptors mediate excitation that results in Ca2+ influx and neurotransmitter release. Ca2+ influx triggered by the activation of embryonic GlyRs is required for the synaptic localization of the GlyR and its anchoring protein gepyhrin. In the adult, mutations in GlyR subunit genes result in motor disorders. The spastic and spasmodic phenotypes in mouse as well as human hereditary startle disease will be discussed.

Details

Title: Structure and functions of inhibitory and excitatory glycine receptors
Authors: H Betz (Author) - MPIH, Germany
J Kuhse (Author)
V Schmieden (Author) - Humboldt-Universität Berlin, Germany
B Laube (Author)
J Kirsch (Author) - Universität Ulm, Germany
Robert J Harvey (Author) - The School of Pharmacy, United Kingdom
Publication details: Annals of the New York Academy of Sciences, Vol.868, pp.667-676
Publisher: Wiley-Blackwell Publishing Inc.
Date published: 1999
DOI: 10.1111/j.1749-6632.1999.tb11343.x
ISSN: 0077-8923
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450529402621
Output Type: Journal article

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