Journal article
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
Nature Communications, Vol.5, 4544
2014
Abstract
Streptococcus agalactiae (Group B Streptococcus, GBS) is a commensal of the digestive and genitourinary tracts of humans that emerged as the leading cause of bacterial neonatal infections in Europe and North America during the 1960s. Due to the lack of epidemiological and genomic data, the reasons for this emergence are unknown. Here we show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.
Details
- Title
- Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline
- Authors
- Violette Da Cunha (Author) - Unite´ de Biologie des Bacteries Pathoge`nes a` Gram-positif, FranceMark R Davies (Author) - University of QueenslandPierre-Emmanuel Douarre (Author) - Unite´ de Biologie des Bacteries Pathoge`nes a` Gram-positif, FranceIsabelle Rosinski-Chupin (Author) - Unite´ de Biologie des Bacteries Pathoge`nes a` Gram-positif, FranceImmaculada Margarit (Author) - Novartis Vaccines and Diagnostics, ItalySebastien Spinali (Author) - Hoˆpitaux Universitaires, FranceTim Perkins (Author) - Novartis Vaccines and Diagnostics, ItalyPierre Lechat (Author) - Institut Pasteur, FranceNicolas Dmytruk (Author) - Hoˆpitaux Universitaires, FranceElisabeth Sauvage (Author) - Unite´ de Biologie des Bacteries Pathoge`nes a` Gram-positif, FranceLaurence Ma (Author) - Institut Pasteur, FranceBenedetta Romi (Author) - Novartis Vaccines and Diagnostics, ItalyMagali Tichit (Author) - Institut Pasteur, FranceMaria-Jose Lopez-Sanchez (Author) - Unite´ de Biologie des Bacteries Pathoge`nes a` Gram-positif, FranceStephane Descorps-Declere (Author) - Institut Pasteur, FranceErika Souche (Author) - Institut Pasteur, FranceCarmen Buchrieser (Author) - Institut Pasteur, FrancePatrick Trieu-Cuot (Author) - Unite´ de Biologie des Bacteries Pathoge`nes a` Gram-positif, FranceIvan Moszer (Author) - Institut Pasteur, FranceDominique Clermont (Author) - Institut Pasteur, FranceDomenic Maione (Author) - Novartis Vaccines and Diagnostics, FranceChristiane Bouchier (Author) - Institut Pasteur, FranceDavid J McMillan (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringJulian Parkhill (Author) - Wellcome Trust Sanger Institute, United KingdomJohn L Telford (Author) - Novartis Vaccines and Diagnostics, ItalyGordan Dougan (Author) - Wellcome Trust Sanger Institute, United KingdomMark J Walker (Author) - University of QueenslandDVANI Consortium (Author)Matthew T G Holden (Author) - Wellcome Trust Sanger Institute, United KingdomClaire Poyart (Author) - Unite´ de Biologie des Bacteries Pathoge`nes a` Gram-positif, FrancePhilippe Glaser (Author) - Unite´ de Biologie des Bacteries Pathoge`nes a` Gram-positif, France
- Publication details
- Nature Communications, Vol.5, 4544; 11
- Publisher
- Nature Publishing Group
- Date published
- 2014
- DOI
- 10.1038/ncomms5544
- ISSN
- 2041-1723
- Copyright note
- Copyright © 2014 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99447775902621
- Output Type
- Journal article
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