Journal article
Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage
Vox Sanguinis, Vol.105(2), pp.150-158
2013
Abstract
Background and Objectives: Transfusion of blood products in particular older products is associated with patient morbidity. Previously, we demonstrated a higher incidence of acute lung injury in lipopolysaccharide-treated sheep transfused with stored blood products. As transfusion following haemorrhage is more common, we aimed to determine whether a 'first hit' of isolated haemorrhage would precipitate similar detrimental effects following transfusion and also disrupt haemostasis. Materials and Methods: Anaesthetized sheep had 33% of their total blood volume collected into Leukotrap bags (Pall Medical), which were processed into packed red blood cells and cross-matched for transfusion into other sheep. After 30 mins, the sheep were resuscitated with either: fresh ( less than 5 days old) or stored (35-42 days old) ovine blood followed by 4% albumin to replacement volume, albumin alone or normal saline alone and monitored for 4 h. Results: The first hit of haemorrhage precipitated substantial decreases in mean arterial pressure however haemostasis was preserved. Transfusion of stored ovine blood induced (1) transient pulmonary arterial hypertension but no oedema and (2) reduced fibrinogen levels more than fresh blood, but neither induced coagulopathy. Thus, transfusion of stored blood affected pulmonary function even in the absence of overt organ injury. Conclusion: The fact that stored blood transfusions: (1) did not induce acute lung injury in contrast to previous lipopolysaccharide-primed animal models identifies the 'first hit' as an important determinant of the severity of transfusion-mediated injury; (2) impaired pulmonary dynamics verifies the sensitivity and vulnerability of the pulmonary system to injury. © 2013 International Society of Blood Transfusion.
Details
- Title
- Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage
- Authors
- Yoke Lin Fung (Author) - University of QueenslandJ P Tung (Author) - University of QueenslandS R Foley (Author) - University of QueenslandG Simonova (Author) - University of QueenslandOgilvie Thom (Author) - University of QueenslandA Staib (Author) - University of QueenslandJ Collier (Author) - University of QueenslandK Dunster (Author) - University of QueenslandC Solano (Author) - University of QueenslandK Shekar (Author) - University of QueenslandM S Chew (Author) - University of QueenslandJ F Fraser (Author) - University of Queensland
- Publication details
- Vox Sanguinis, Vol.105(2), pp.150-158
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2013
- DOI
- 10.1111/vox.12032
- ISSN
- 0042-9007
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99448950702621
- Output Type
- Journal article
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- Hematology
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