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Published VersionCC BY V4.0, Open Access
Journal article
Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo
Biocybernetics and Biomedical Engineering, Vol.44(3), pp.609-616
2024
Abstract
Significance
The biomechanical properties of the cornea are important for vision and ocular health. Optical coherence elastography (OCE) has the potential to improve our capacity to measure these properties.
Aim
This study tested a static compression OCE method utilising a commercially available optical coherence tomography (OCT) device, to estimate the Young’s modulus of ex-vivo porcine corneal tissue.
Approach: OCT was used to image corneal tissue samples before and during loading by static compression. The compressive force was measured with a piezoresistive force sensor, and tissue deformation was quantified through automated image analysis. Ten ex-vivo porcine corneas were assessed and the corneal thickness was also measured to assess the impact of corneal swelling.
Results
An average (standard deviation) Young’s modulus of 0.271 (+/- 0.091) MPa was determined across the 10 corneas assessed. There was a mean decrease of 1.78 % in corneal thickness at the end of the compression series. These results showed that there was a moderate association between corneal thickness and the Young’s modulus recording (R2 = 0.274).
Conclusions
Optical coherence elastography utilising clinical instrumentation, can reliably characterise the mechanical properties of the cornea. These results support the further investigation of the technique for in-vivo measurement of the mechanical properties of the human cornea.
Details
- Title
- Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo
- Authors
- Zachery Quince (Corresponding Author) - University of Southern QueenslandDavid Alonso-Caneiro (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringScott A. Read (Author) - Queensland University of TechnologyDamien G. Harkin (Author) - Queensland University of TechnologyMichael J. Collins (Author) - Queensland University of Technology
- Publication details
- Biocybernetics and Biomedical Engineering, Vol.44(3), pp.609-616
- Publisher
- Elsevier BV
- Date published
- 2024
- DOI
- 10.1016/j.bbe.2024.08.006
- ISSN
- 0208-5216
- Copyright note
- © 2024 The Author(s). Published by Elsevier B.V. on behalf of Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 991060560202621
- Output Type
- Journal article
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