Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

J K Klint; S Senff; D B Rupasinghe; S Y Er; Volker Herzig; G M Nicholson; G F King

doi:10.1016/j.toxicon.2012.04.337

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Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

Journal article

Open access

Peer reviewed

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

J K Klint, S Senff, D B Rupasinghe, S Y Er, Volker Herzig, G M Nicholson and G F King

Toxicon, Vol.60(4), pp.478-491

2012

DOI: https://doi.org/10.1016/j.toxicon.2012.04.337

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Abstract

spider venom

peptide

inhibitor cystine knot

voltage-gated sodium channel

therapeutic

analgesic

insecticide

ArachnoServer

NaV1.7

Voltage-gated sodium (Na V) channels play a central role in the propagation of action potentials in excitable cells in both humans and insects. Many venomous animals have therefore evolved toxins that modulate the activity of Na V channels in order to subdue their prey and deter predators. Spider venoms in particular are rich in Na V channel modulators, with one-third of all known ion channel toxins from spider venoms acting on Na V channels. Here we review the landscape of spider-venom peptides that have so far been described to target vertebrate or invertebrate Na V channels. These peptides fall into 12 distinct families based on their primary structure and cysteine scaffold. Some of these peptides have become useful pharmacological tools, while others have potential as therapeutic leads because they target specific Na V channel subtypes that are considered to be important analgesic targets. Spider venoms are conservatively predicted to contain more than 10 million bioactive peptides and so far only 0.01% of this diversity been characterised. Thus, it is likely that future research will reveal additional structural classes of spider-venom peptides that target Na V channels.

Details

Title: Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads
Authors: J K Klint (Author) - University of Queensland
S Senff (Author) - University of Queensland
D B Rupasinghe (Author) - University of Queensland
S Y Er (Author) - University of Queensland
Volker Herzig (Author) - University of Queensland
G M Nicholson (Author) - University of Technology, Sydney
G F King (Author) - University of Queensland
Publication details: Toxicon, Vol.60(4), pp.478-491
Publisher: Elsevier Ltd.
Date published: 2012
DOI: 10.1016/j.toxicon.2012.04.337
ISSN: 0041-0101
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451156302621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Pharmacology & Pharmacy; Toxicology

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