Spider-venom peptides as therapeutics

N J Saez; S Senff; J E Jensen; S Y Er; Volker Herzig; L D Rash; G F King

doi:10.3390/toxins2122851

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Journal article

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Peer reviewed

Spider-venom peptides as therapeutics

N J Saez, S Senff, J E Jensen, S Y Er, Volker Herzig, L D Rash and G F King

Toxins, Vol.2(12), pp.2851-2871

2010

DOI: https://doi.org/10.3390/toxins2122851

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Abstract

spider venom

peptide

therapeutics

drugs

drug discovery

cystine knot

Spiders are the most successful venomous animals and the most abundant terrestrial predators. Their remarkable success is due in large part to their ingenious exploitation of silk and the evolution of pharmacologically complex venoms that ensure rapid subjugation of prey. Most spider venoms are dominated by disulfide-rich peptides that typically have high affinity and specificity for particular subtypes of ion channels and receptors. Spider venoms are conservatively predicted to contain more than 10 million bioactive peptides, making them a valuable resource for drug discovery. Here we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against a wide range of pathophysiological conditions including cardiovascular disorders, chronic pain, inflammation, and erectile dysfunction.

Details

Title: Spider-venom peptides as therapeutics
Authors: N J Saez (Author) - University of Queensland
S Senff (Author) - University of Queensland
J E Jensen (Author) - University of Queensland
S Y Er (Author) - University of Queensland
Volker Herzig (Author) - University of Queensland
L D Rash (Author) - University of Queensland
G F King (Author) - University of Queensland
Publication details: Toxins, Vol.2(12), pp.2851-2871
Publisher: MDPI AG
Date published: 2010
DOI: 10.3390/toxins2122851
ISSN: 2072-6651
Copyright note: Copyright © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451328702621
Output Type: Journal article

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