Spider-venom peptides as bioinsecticides

M J Windley; Volker Herzig; S A Dziemborowicz; M C Hardy; G F King; G M Nicholson

doi:10.3390/toxins4030191

Back

Spider-venom peptides as bioinsecticides

Journal article

Open access

Peer reviewed

Spider-venom peptides as bioinsecticides

M J Windley, Volker Herzig, S A Dziemborowicz, M C Hardy, G F King and G M Nicholson

Toxins, Vol.4(3), pp.191-227

2012

DOI: https://doi.org/10.3390/toxins4030191

Files and links (2)

pdf

PDF - Published Version (Open Access)888.08 kBDownload View

Published VersionPDF - Published Version (Open Access)CC BY V3.0, Open Access

url

https://doi.org/10.3390/toxins4030191View

Published Version

Abstract

spider venom

peptide

insecticidal

bioinsecticides

cystine knot

pest control

Over 10,000 arthropod species are currently considered to be pest organisms. They are estimated to contribute to the destruction of ~14% of the world's annual crop production and transmit many pathogens. Presently, arthropod pests of agricultural and health significance are controlled predominantly through the use of chemical insecticides. Unfortunately, the widespread use of these agrochemicals has resulted in genetic selection pressure that has led to the development of insecticide-resistant arthropods, as well as concerns over human health and the environment. Bioinsecticides represent a new generation of insecticides that utilise organisms or their derivatives (e.g., transgenic plants, recombinant baculoviruses, toxin-fusion proteins and peptidomimetics) and show promise as environmentally-friendly alternatives to conventional agrochemicals. Spider-venom peptides are now being investigated as potential sources of bioinsecticides. With an estimated 100,000 species, spiders are one of the most successful arthropod predators. Their venom has proven to be a rich source of hyperstable insecticidal mini-proteins that cause insect paralysis or lethality through the modulation of ion channels, receptors andenzymes. Many newly characterized insecticidal spider toxins target novel sites in insects. Here we review the structure and pharmacology of these toxins and discuss the potential of this vast peptide library for the discovery of novel bioinsecticides.

Details

Title: Spider-venom peptides as bioinsecticides
Authors: M J Windley (Author) - University of Technology, Sydney
Volker Herzig (Author) - University of Queensland
S A Dziemborowicz (Author) - University of Technology, Sydney
M C Hardy (Author) - University of Queensland
G F King (Author) - University of Queensland
G M Nicholson (Author) - University of Technology, Sydney
Publication details: Toxins, Vol.4(3), pp.191-227
Publisher: MDPI AG
Date published: 2012
DOI: 10.3390/toxins4030191
ISSN: 2072-6651; 2072-6651
Copyright note: Copyright © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451329702621
Output Type: Journal article
Research Statement: false

Metrics

13 File views/ downloads

53 Record Views

187 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Food Science & Technology; Toxicology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites