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Spatial Cluster Patterns of Retinal Sensitivity Loss in Intermediate Age-Related Macular Degeneration Features1.82 MB
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Spatial Cluster Patterns of Retinal Sensitivity Loss in Intermediate Age-Related Macular Degeneration Features
Translational Vision Science & Technology, Vol.12(9), pp.1-17
2023
PMID: 37676679
Abstract
Purpose: To examine spatial patterns of retinal sensitivity loss in the three key features of intermediate age-related macular degeneration (iAMD).
Methods: One-hundred individuals (53 iAMD, 47 normal) underwent 10-2 mesopic microperimetry testing in one eye. Pointwise sensitivities (dB) were corrected for age, sex, iAMD status, and co-presence of co-localized key iAMD features: drusen load, pigmentary abnormalities, and reticular pseudodrusen (RPD). Clusters (labeled by ranks of magnitude C-2, C-1, C0) were derived from pointwise sensitivities and then assessed by quadrants and eccentricity/rings.
Results: Two clusters of decreased sensitivities were evident in iAMD versus normal: C-2, -1.67 dB (95% CI (confidence intervals), -2.36 to -0.98; P < 0.0001); C-1, -0.93 dB (95% CI, -1.5 to -0.36; P < 0.01). One cluster of decreased sensitivity was independently associated each with increased drusen load (13.57 µm increase per -1 dB; P < 0.0001), pigmentary abnormalities (C-1: -2.23 dB; 95% CI, -3.36 to -1.1; P < 0.01), and RPD (C-1: -1.07 dB; 95% CI, -2 to -0.14; P < 0.01). Sensitivity loss in iAMD was biased toward the superior and central macula (P = 0.16 to <0.0001), aligning with structural distributions of features. However, sensitivity loss associated with drusen load also extended to the peripheral macula (P < 0.0001) with paracentral sparing, which was discordant with the central distribution of drusen.
Conclusions: Drusen load, pigmentary abnormalities, and RPD are associated with patterns of retinal sensitivity loss commonly demonstrating superior and central bias. Results highlighted that a clinical focus on these three key iAMD features using structural measures alone does not capture the complex, spatial extent of vision-related functional impairment in iAMD.
Translational relevance: Defining the spatial patterns of retinal sensitivity loss in iAMD can facilitate a targeted visual field protocol for iAMD assessment.
Details
- Title
- Spatial Cluster Patterns of Retinal Sensitivity Loss in Intermediate Age-Related Macular Degeneration Features
- Authors
- Matt Trinh (Author) - UNSW SydneyMichael Kalloniatis (Author) - UNSW SydneyDavid Alonso-Caneiro (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringLisa Nivison-Smith (Corresponding Author) - UNSW Sydney
- Publication details
- Translational Vision Science & Technology, Vol.12(9), pp.1-17
- Publisher
- Association for Research in Vision and Ophthalmology
- Date published
- 2023
- DOI
- 10.1167/tvst.12.9.6
- ISSN
- 2164-2591
- PMID
- 37676679
- Copyright note
- This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
- Grant note
- 1186915, 1174385 / National Health and Medical Research Council of Australia Australian Research Training Program scholarship
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99966894802621
- Output Type
- Journal article
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