Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

Mark W Logue; Sanne J H van Rooij; Emily L Dennis; Sarah L Davis; Jasmeet P Hayes; Jennifer S Stevens; Maria Densmore; Courtney C Haswell; Jonathan Ipser; Saskia B J Koch; Mayuresh Korgaonkar; Lauren A M Lebois; Matthew Peverill; Justin T Baker; Premika S W Boedhoe; Jessie L Frijling; Staci A Gruber; Ilan Harpaz-Rotem; Neda Jahanshad; Sheri Koopowitz; Ifat Levy; Laura Nawijn; Lauren O'Connor; Miranda Olff; David H Salat; Margaret A Sheridan; Jeffrey M Spielberg; Mirjam van Zuiden; Sherry R Winternitz; Jonathan D Wolff; Erika J Wolf; Xin Wang; Kristen Wrocklage; Chadi G Abdallah; Richard A Bryant; Elbert Gueze; Tanja Jovanovic; Milissa L Kaufman; Anthony P King; John H Krystal; Jim Lagopoulos; Maxwell Bennett; Ruth Lanius; Israel Liberzon; Regina E McGlinchey; Katie A McLaughlin; William P Milberg; Mark W Miller; Kerry J Ressler; Dick J Veltman; Dan J Stein; Kathleen Thomaes; Paul M Thompson; Rajendra A Morey

doi:10.1016/j.biopsych.2017.09.006

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Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

Journal article

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Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

Mark W Logue, Sanne J H van Rooij, Emily L Dennis, Sarah L Davis, Jasmeet P Hayes, Jennifer S Stevens, Maria Densmore, Courtney C Haswell, Jonathan Ipser, Saskia B J Koch, …

Biological Psychiatry, Vol.83(3), pp.244-253

2018

DOI: https://doi.org/10.1016/j.biopsych.2017.09.006

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Abstract

Biological Sciences

Medical and Health Sciences

Psychology and Cognitive Sciences

Amygdala

childhood trauma

gender differences

hippocampus

PTSD

structural MRI

BACKGROUND-Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through MetaAnalysis (ENIGMA) PTSD Working Group. METHODS-We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized imageanalysis and quality-control pipeline established by the ENIGMA consortium. RESULTS-In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = -0.17, p = .00054), and smaller amygdalae (d = -0.11, p = .025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p < .0063). CONCLUSIONS-Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

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Title: Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia
Authors: Mark W Logue (Author) - VA Boston Healthcare System, United States
Sanne J H van Rooij (Author) - Emory University, United States
Emily L Dennis (Author) - University of Southern California, United States
Sarah L Davis (Author) - Durham VA Medical Centre, United States
Jasmeet P Hayes (Author) - VA Boston Healthcare System, United States
Jennifer S Stevens (Author) - Emory University, United States
Maria Densmore (Author) - University of Western Ontario, Canada
Courtney C Haswell (Author) - Durham VA Medical Centre, United States
Jonathan Ipser (Author) - University of Cape Town, South Africa
Saskia B J Koch (Author) - Academic Medical Centre, Netherlands
Mayuresh Korgaonkar (Author) - Westmead Institute for Medical Research
Lauren A M Lebois (Author) - Harvard Medical School, United States
Matthew Peverill (Author) - University of Washington, United States
Justin T Baker (Author) - Harvard University, United States
Premika S W Boedhoe (Author) - VU University Medical Centre, Netherlands
Jessie L Frijling (Author) - Academic Medical Centre, Netherlands
Staci A Gruber (Author) - Harvard University, United States
Ilan Harpaz-Rotem (Author) - VA Connecticut HealthCare System, United States
Neda Jahanshad (Author) - University of Southern California, United States
Sheri Koopowitz (Author) - University of Cape Town, South Africa
Ifat Levy (Author) - VA Connecticut HealthCare System, United States
Laura Nawijn (Author) - Academic Medical Centre, Netherlands
Lauren O'Connor (Author) - City University of New York, United States
Miranda Olff (Author) - Academic Medical Centre, Netherlands
David H Salat (Author) - VA Boston Healthcare System, United States
Margaret A Sheridan (Author) - University of North Carolina, United States
Jeffrey M Spielberg (Author) - VA Boston Healthcare System, United States
Mirjam van Zuiden (Author) - Academic Medical Centre, Netherlands
Sherry R Winternitz (Author) - Harvard University, United States
Jonathan D Wolff (Author) - Harvard Medical School, United States
Erika J Wolf (Author) - VA Boston Healthcare System, United States
Xin Wang (Author) - University of Toledo, United States
Kristen Wrocklage (Author) - VA Connecticut HealthCare System, United States
Chadi G Abdallah (Author) - VA Connecticut HealthCare System, United States
Richard A Bryant (Author) - University of New South Wales
Elbert Gueze (Author) - University Medical Centre, Netherlands
Tanja Jovanovic (Author) - Emory University, United States
Milissa L Kaufman (Author) - Harvard Medical School, United States
Anthony P King (Author) - University of Michigan, United States
John H Krystal (Author) - VA Connecticut HealthCare System, United States
Jim Lagopoulos (Author) - University of Sydney
Maxwell Bennett (Author) - University of Sydney
Ruth Lanius (Author) - VA Boston Healthcare System, United States
Israel Liberzon (Author) - University of Michigan, United States
Regina E McGlinchey (Author) - VA Boston Healthcare System, United States
Katie A McLaughlin (Author) - University of Washington, United States
William P Milberg (Author) - VA Boston Healthcare System, United States
Mark W Miller (Author) - VA Boston Healthcare System, United States
Kerry J Ressler (Author) - Harvard University, United States
Dick J Veltman (Author) - VU University Medical Centre, Netherlands
Dan J Stein (Author) - University of Cape Town, South Africa
Kathleen Thomaes (Author) - VU University Medical Centre, Netherlands
Paul M Thompson (Author) - University of Southern California, United States
Rajendra A Morey (Author) - Durham VA Medical Centre, United States
Publication details: Biological Psychiatry, Vol.83(3), pp.244-253
Publisher: Elsevier Inc.
Date published: 2018
DOI: 10.1016/j.biopsych.2017.09.006
ISSN: 0006-3223
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451249302621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neurosciences; Psychiatry

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