Sleep–wake cycle phenotypes in young people with familial and non-familial mood disorders

Jan Scott; S Naismith; A Grierson; J Carpenter; Daniel F Hermens; E Scott; I Hickie

doi:10.1111/bdi.12450

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Sleep–wake cycle phenotypes in young people with familial and non-familial mood disorders

Journal article

Peer reviewed

Sleep–wake cycle phenotypes in young people with familial and non-familial mood disorders

Jan Scott, S Naismith, A Grierson, J Carpenter, Daniel F Hermens, E Scott and I Hickie

Bipolar Disorders, Vol.18(8), pp.642-649

2016

DOI: https://doi.org/10.1111/bdi.12450

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Abstract

actigraphy

bipolar disorder

circadian

familial

offspring

phenotypes

sleep

sleep homeostasis

unipolar disorder

Pittsburgh Sleep Quality Index (PSQI)

Objectives: Converging evidence identifies that the offspring of parents with bipolar disorder (BD), individuals at clinical high risk of BD, and young people with recent onset BD may differ from other clinical cases or healthy controls in terms of sleep-wake profiles. However, it is possible that these differences may reflect current mental state, subtype of mood disorder, or familial traits. This study aimed to determine objective and subjective sleep-wake profiles in individuals aged 15-25 years with a current major depressive episode, in relation to familial traits. Methods: Frequency matching was employed to ensure that each individual with a confirmed family history of BD (FH+) could be compared to four controls who did not have a familial mood disorder (FH-). Pre-selected objective actigraphy and subjective Pittsburgh Sleep Quality Index (PSQI) ratings were compared using one-way analysis of variance (ANOVA) and applying the Benjamini-Hochberg (BH) correction for false discoveries. Results: The sample comprised 60 individuals with a mean age of 19 years. The FH+ (n=12) and FH- groups (n=48) differed on three key sleep parameters: mean sleep duration on week nights (P=.049), variability in waking after sleep onset (P=.038), and daily disturbances (PSQI dimension of sleep disturbance and daytime dysfunction; P=.01). Conclusions: The sleep profiles we identified in this study, especially the daily disturbances phenotype, provide support for research into endophenotypes for BD. Also, the findings may offer the opportunity for more tailored, personalized interventions that target specific components of the sleep-wake cycle in individuals with a family history of BD. © 2016 John Wiley &Sons A/S. Published by John Wiley &Sons Ltd

Details

Title: Sleep–wake cycle phenotypes in young people with familial and non-familial mood disorders
Authors: Jan Scott (Author) - Newcastle University, United Kingdom
S Naismith (Author) - University of Sydney
A Grierson (Author) - University of Sydney
J Carpenter (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
E Scott (Author) - University of Sydney
I Hickie (Author) - University of Sydney
Publication details: Bipolar Disorders, Vol.18(8), pp.642-649
Publisher: Wiley-Blackwell Publishing Inc.
Date published: 2016
DOI: 10.1111/bdi.12450
ISSN: 1399-5618
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451172202621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences; Psychiatry

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