Sleep-wake profiles and circadian rhythms of core temperature and melatonin in young people with affective disorders

J S Carpenter; R Robillard; Daniel F Hermens; S L Naismith; C Gordon; E M Scott; I B Hickie

doi:10.1016/j.jpsychires.2017.07.007

Back

Sleep-wake profiles and circadian rhythms of core temperature and melatonin in young people with affective disorders

Journal article

Peer reviewed

Sleep-wake profiles and circadian rhythms of core temperature and melatonin in young people with affective disorders

J S Carpenter, R Robillard, Daniel F Hermens, S L Naismith, C Gordon, E M Scott and I B Hickie

Journal of Psychiatric Research, Vol.94, pp.131-138

2017

DOI: https://doi.org/10.1016/j.jpsychires.2017.07.007

Files and links (1)

url

https://doi.org/10.1016/j.jpsychires.2017.07.007View

Published Version

Abstract

sleep

circadian

melatonin

core temperature

affective disorders

While disturbances of the sleep-wake cycle are common in people with affective disorders, the characteristics of these disturbances differ greatly between individuals. This heterogeneity is likely to reflect multiple underlying pathophysiologies, with different perturbations in circadian systems contributing to the variation in sleep-wake cycle disturbances. Such disturbances may be particularly relevant in adolescents and young adults with affective disorders as circadian rhythms undergo considerable change during this key developmental period. This study aimed to identify profiles of sleep-wake disturbance in young people with affective disorders and investigate associations with biological circadian rhythms. Fifty young people with affective disorders and 19 control participants (aged 16-31 years) underwent actigraphy monitoring for approximately two weeks to derive sleep-wake cycle parameters, and completed an in-laboratory assessment including evening dim-light saliva collection for melatonin assay and overnight continuous core body temperature measurement. Cluster analysis based on sleep-wake cycle parameters identified three distinct patient groups, characterised by 'delayed sleep-wake', 'disrupted sleep', and 'long sleep' respectively. The 'delayed sleep-wake' group had both delayed melatonin onset and core temperature nadir; whereas the other two cluster groups did not differ from controls on these circadian markers. The three groups did not differ on clinical characteristics. These results provide evidence that only some types of sleep-wake disturbance in young people with affective disorders are associated with fundamental circadian perturbations. Consequently, interventions targeting endogenous circadian rhythms to promote a phase shift may be particularly relevant in youth with affective disorders presenting with delayed sleep-wake cycles. © 2017 Elsevier Ltd

Details

Title: Sleep-wake profiles and circadian rhythms of core temperature and melatonin in young people with affective disorders
Authors: J S Carpenter (Author) - University of Sydney
R Robillard (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
S L Naismith (Author) - University of Sydney
C Gordon (Author) - University of Sydney
E M Scott (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Publication details: Journal of Psychiatric Research, Vol.94, pp.131-138
Publisher: Pergamon
Date published: 2017
DOI: 10.1016/j.jpsychires.2017.07.007
ISSN: 0022-3956
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450469702621
Output Type: Journal article

Metrics

3 File views/ downloads

1467 Record Views

35 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites