Journal article
Sleep-wake cycle in young and older persons with a lifetime history of mood disorders
PLoS One, Vol.9(2), e87763
2014
Abstract
Considering the marked changes in sleep and circadian rhythms across the lifespan, age may contribute to the heterogeneity in sleep-wake profiles linked to mood disorders. This study aimed to investigate the contributions of age and depression severity to sleep-wake disturbances. The Hamilton Depression Rating Scale (HDRS) was administered to assess current symptoms severity in 238 persons with a history of a mood disorder between 12 and 90 years of age (y.o.). Actigraphy was recorded over five to 22 days. Regression analyses and analyses of variance [age (12-19 y.o., 20-39 y.o., 40-59 y.o., and ≥60 y.o.) by depression severity (HDRS< and ≥8)] were conducted. The 12-19 y.o. and 20-39 y.o. groups had a delayed sleep schedule and acrophase compared to all other groups. The ≥60 y.o. group had a lower rhythmicity and amplitude (p≤.006) than the 12-19 y.o. group (p≤.046). Participants with a HDRS≥8 spent longer time in bed, had later sleep offset times and had lower circadian rhythmicity than those with a HDRS<8 (p≤.036). Younger age and higher HDRS score correlated with later sleep onset and offset times, longer time in bed, higher WASO, lower sleep efficiency and later acrophase (p≤.023). Age was a significant predictor of delayed sleep and activity schedules (p≤.001). The profile of sleep-wake cycle disturbances associated with mood disorders changes with age, with prominent sleep phase delay during youth and reduced circadian strength in older persons. Conversely, disruptions in sleep consolidation seem more stable across age. © 2014 Robillard et al.
Details
- Title
- Sleep-wake cycle in young and older persons with a lifetime history of mood disorders
- Authors
- R Robillard (Author) - University of SydneyS L Naismith (Author) - University of SydneyK L Smith (Author) - University of SydneyN L Rogers (Author) - University of SydneyD White (Author) - University of SydneyZ Terpening (Author) - University of SydneyT K C Ip (Author) - University of SydneyDaniel F Hermens (Author) - University of SydneyB Whitwell (Author) - University of SydneyE M Scott (Author) - University of SydneyI B Hickie (Author) - University of Sydney
- Publication details
- PLoS One, Vol.9(2), e87763; 8
- Publisher
- Public Library of Science
- Date published
- 2014
- DOI
- 10.1371/journal.pone.0087763
- ISSN
- 1932-6203
- Copyright note
- Copyright © 2014 Robillard et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99451065902621
- Output Type
- Journal article
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- Psychiatry
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