Skeletal muscle mitochondrial ATP production rate and walking performance in peripheral arterial disease

X Y Hou; S Green; Christopher D Askew; G A Barker; A Green; P J Walker

doi:10.1046/j.1475-097X.2002.00423.x

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Skeletal muscle mitochondrial ATP production rate and walking performance in peripheral arterial disease

Journal article

Peer reviewed

Skeletal muscle mitochondrial ATP production rate and walking performance in peripheral arterial disease

X Y Hou, S Green, Christopher D Askew, G A Barker, A Green and P J Walker

Clinical Physiology and Functional Imaging, Vol.22(3), pp.226-232

2002

DOI: https://doi.org/10.1046/j.1475-097X.2002.00423.x

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Abstract

Medical Physiology

peripheral arterial disease

ATP production

skeletal muscle

This study tested the hypotheses that skeletal muscle mitochondrial ATP production rate (MAPR) is impaired in patients with peripheral arterial disease (PAD) and that it relates positively to their walking performances. Seven untrained patients, eight exercise-trained patients and 11 healthy controls completed a maximal walking test and had muscle sampled from the gastrocnemius medialis muscle. Muscle was analysed for its MAPR in the presence of pyruvate, palmitoyl-L-carnitine or both, as well as citrate synthase (CS) activity. MAPRs were not different between untrained PAD and controls. In contrast, MAPRs (pyruvate) were significantly higher in trained PAD vs. controls. MAPR (pyruvate combinations) was also significantly higher in trained than untrained PAD muscle. MAPR and CS activity were highly correlated with walking performance in patients, but not in controls. These data do not support the hypothesis that isolated mitochondria are functionally impaired in PAD and demonstrate that the muscle mitochondrial capacity to oxidize carbohydrate is positively related to walking performance in these patients.

Details

Title: Skeletal muscle mitochondrial ATP production rate and walking performance in peripheral arterial disease
Authors: X Y Hou (Author) - Queensland University of Technology
S Green (Author) - Queensland University of Technology
Christopher D Askew (Author) - Queensland University of Technology
G A Barker (Author) - Queensland University of Technology
A Green (Author) - Queensland University of Technology
P J Walker (Author) - University of Queensland
Publication details: Clinical Physiology and Functional Imaging, Vol.22(3), pp.226-232
Publisher: Blackwell Publishing Ltd.
Date published: 2002
DOI: 10.1046/j.1475-097X.2002.00423.x
ISSN: 1475-0961
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449626102621
Output Type: Journal article

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Web Of Science research areas: Physiology

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