Six-week oral ketamine treatment for chronic suicidality is associated with increased grey matter volume

Cyrana C Gallay; Grace Forsyth; Adem T Can; Megan Dutton; Daniel Jamieson; Emma Jensen; Daniel F Hermens; Maxwell R Bennett; Jim Lagopoulos

doi:10.1016/j.pscychresns.2021.111369

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Six-week oral ketamine treatment for chronic suicidality is associated with increased grey matter volume

Journal article

Peer reviewed

Six-week oral ketamine treatment for chronic suicidality is associated with increased grey matter volume

Cyrana C Gallay, Grace Forsyth, Adem T Can, Megan Dutton, Daniel Jamieson, Emma Jensen, Daniel F Hermens, Maxwell R Bennett and Jim Lagopoulos

Psychiatry Research: Neuroimaging, Vol.317, pp.1-4

2021

DOI: https://doi.org/10.1016/j.pscychresns.2021.111369

PMID: 34461430

Appears in Thompson Institute Research Collection

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Abstract

depression

glutamate

magnetic resonance imaging (MRI)

Suicide prevention

Ketamine

Neuroimaging

Thompson Institute Special Collection

Chronic suicidality has been associated with neuronal atrophy in cortico-striato-limbic regions and is thought to be mediated via a glutamatergic imbalance. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been posited to exert anti-suicidal effects by promoting neurogenesis via modulation of glutamatergic transmission. This voxel-based morphometry study examined the effect of ketamine on whole brain grey matter in adults with chronic suicidality. Grey matter in the periaqueductal grey, nucleus accumbens, putamen, caudate, and thalamus was significantly increased following 6 weeks of low dose oral ketamine treatment. These results support the notion that ketamine rapidly enhances synaptic plasticity within striato-limbic regions.

Details

Title: Six-week oral ketamine treatment for chronic suicidality is associated with increased grey matter volume
Authors: Cyrana C Gallay (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Grace Forsyth (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Adem T Can (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Megan Dutton (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Daniel Jamieson (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Emma Jensen (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Daniel F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Maxwell R Bennett (Author) - The University of Sydney
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Publication details: Psychiatry Research: Neuroimaging, Vol.317, pp.1-4
Publisher: Elsevier Ireland Ltd.
Date published: 2021
DOI: 10.1016/j.pscychresns.2021.111369
ISSN: 1872-7506
PMID: 34461430
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99569208202621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology; Neuroimaging; Psychiatry

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