Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: 'OPTIMISE your health' trial protocol

Christian J Brakenridge; Paul A Gardiner; Ruth V Grigg; Elisabeth Winkler; Brianna S Fjeldsoe; Mia Schaumberg; Neville Owen; Elizabeth Eakin; Stuart J H Biddle; Marjory Moodie; Robin M Daly; Daniel J Green; Neale Cohen; Len Gray; Tracy Comans; Matthew P Buman; Ana D Goode; Phuong Nguyen; Lan Gao; Genevieve N Healy; David Dunstan

doi:10.1186/s12889-022-13123-x

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Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: 'OPTIMISE your health' trial protocol

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Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: 'OPTIMISE your health' trial protocol

Christian J Brakenridge, Paul A Gardiner, Ruth V Grigg, Elisabeth Winkler, Brianna S Fjeldsoe, Mia Schaumberg, Neville Owen, Elizabeth Eakin, Stuart J H Biddle, Marjory Moodie, …

BMC Public Health, Vol.22(1), pp.1-23

2022

DOI: https://doi.org/10.1186/s12889-022-13123-x

PMCID: PMC9086419

PMID: 35538430

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Abstract

cognitive function

glycaemic control

sedentary behaviour

type 2 diabetes

Background: Clinical practice guidelines recommend that adults with type 2 diabetes (T2D) sit less and move more throughout the day. The 18-month OPTIMISE Your Health Clinical Trial was developed to support desk-based workers with T2D achieve these recommendations. The two-arm protocol consists of an intervention and control arms. The intervention arm receives 6 months health coaching, a sit-stand desktop workstation and an activity tracker, followed by 6 months of text message support, then 6 months maintenance. The control arm receives a delayed modified intervention after 12 months of usual care. This paper describes the methods of a randomised controlled trial (RCT) evaluating the effectiveness and cost-effectiveness of the intervention, compared to a delayed intervention control. Methods: This is a two-arm RCT being conducted in Melbourne, Australia. Desk-based workers (≥0.8 full-time equivalent) aged 35-65 years, ambulatory, and with T2D and managed glycaemic control (6.5-10.0% HbA1c), are randomised to the multicomponent intervention (target n = 125) or delayed-intervention control (target n = 125) conditions. All intervention participants receive 6 months of tailored health coaching assisting them to "sit less" and "move more" at work and throughout the day, supported by a sit-stand desktop workstation and an activity tracker (Fitbit). Participants receive text message-based extended care for a further 6-months (6-12 months) followed by 6-months of non-contact (12-18 months: maintenance). Delayed intervention occurs at 12-18 months for the control arm. Assessments are undertaken at baseline, 3, 6, 12, 15 and 18-months. Primary outcomes are activPAL-measured sitting time (h/16 h day), glycosylated haemoglobin (HbA1c; %, mmol/mol) and, cognitive function measures (visual learning and new memory; Paired Associates Learning Total Errors [adjusted]). Secondary, exploratory, and process outcomes will also be collected throughout the trial. Discussion: The OPTIMISE Your Health trial will provide unique insights into the benefits of an intervention aimed at sitting less and moving more in desk-bound office workers with T2D, with outcomes relevant to glycaemic control, and to cardiometabolic and brain health. Findings will contribute new insights to add to the evidence base on initiating and maintaining behaviour change with clinical populations and inform practice in diabetes management.

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Title: Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: 'OPTIMISE your health' trial protocol
Authors: Christian J Brakenridge (Corresponding Author) - Australian Catholic University
Paul A Gardiner (Author) - University of Southern Queensland
Ruth V Grigg (Author) - Baker Heart and Diabetes Institute
Elisabeth Winkler (Author) - The University of Queensland
Brianna S Fjeldsoe (Author) - The University of Queensland
Mia Schaumberg (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Neville Owen (Author) - Swinburne University of Technology
Elizabeth Eakin (Author) - The University of Queensland
Stuart J H Biddle (Author) - University of Southern Queensland
Marjory Moodie (Author) - Deakin University
Robin M Daly (Author) - Deakin University
Daniel J Green (Author) - The University of Western Australia
Neale Cohen (Author) - Baker Heart and Diabetes Institute
Len Gray (Author) - The University of Queensland
Tracy Comans (Author) - The University of Queensland
Matthew P Buman (Author) - Arizona State University
Ana D Goode (Author) - The University of Queensland
Phuong Nguyen (Author) - Deakin University
Lan Gao (Author) - Deakin University
Genevieve N Healy (Author) - The University of Queensland
David Dunstan (Author) - Monash University
Publication details: BMC Public Health, Vol.22(1), pp.1-23
Publisher: BioMed Central Ltd.
Date published: 2022
DOI: 10.1186/s12889-022-13123-x
ISSN: 1471-2458
PMID: 35538430; PMC9086419
Copyright note: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; Cancer Research Cluster; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99637977502621
Output Type: Journal article

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