Sintering and biocompatibility of blended elemental Ti-xNb alloys

Yunhui Chen; Pingping Han; Ali Dehghan-Manshadi; Damon Kent; Shima Ehtemam Haghighi; Casey Jowers; Michael Bermingham; Tong Li; Justin Cooper-White; Matthew S Dargusch

doi:10.1016/j.jmbbm.2020.103691

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Sintering and biocompatibility of blended elemental Ti-xNb alloys

Journal article

Peer reviewed

Sintering and biocompatibility of blended elemental Ti-xNb alloys

Yunhui Chen, Pingping Han, Ali Dehghan-Manshadi, Damon Kent, Shima Ehtemam Haghighi, Casey Jowers, Michael Bermingham, Tong Li, Justin Cooper-White and Matthew S Dargusch

Journal of the Mechanical Behavior of Biomedical Materials, Vol.104, 103691

2020

DOI: https://doi.org/10.1016/j.jmbbm.2020.103691

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Abstract

titanium

niobium

powder metallurgy

sintering

mechanical properties

biocompatibility

Titanium-niobium (Ti-Nb) alloys have great potential for biomedical applications due to their superior biocompatibility and mechanical properties that match closely to human bone. Powder metallurgy is an ideal technology for efficient manufacture of titanium alloys to generate net-shape, intricately featured and porous components. This work reports on the effects of Nb concentrations on sintered Ti-xNb alloys with the aim to establish an optimal composition in respect to mechanical and biological performances. Ti-xNb alloys with 33, 40, 56 and 66 wt% Nb were fabricated from elemental powders and the sintering response, mechanical properties, microstructures and biocompatibility assessed and compared to conventional commercial purity titanium (CPTi). The sintered densities for all Ti-xNb compositions were around 95%, reducing slightly with increasing Nb due to increasing open porosity. Higher Nb levels retarded sintering leading to more inhomogeneous phase and pore distributions. The compressive strength decreased with increasing Nb, while all Ti-xNb alloys displayed higher strengths than CPTi except the Ti-66Nb alloy. The Young's moduli of the Ti-xNb alloys with ≥40 wt% Nb were substantially lower (30-50%) than CPTi. In-vitro cell culture testing revealed excellent biocompatibility for all Ti-xNb alloys comparable or better than tissue culture plate and CPTi controls, with the Ti-40Nb alloy exhibiting superior cell-material interactions. In view of its mechanical and biological performance, the Ti-40Nb composition is most promising for hard tissue engineering applications.

Details

Title: Sintering and biocompatibility of blended elemental Ti-xNb alloys
Authors: Yunhui Chen (Author) - University of Queensland
Pingping Han (Author) - University of Queensland
Ali Dehghan-Manshadi (Author) - University of Queensland
Damon Kent (Author) - University of the Sunshine Coast - School of Science and Engineering
Shima Ehtemam Haghighi (Author) - University of the Sunshine Coast - School of Science and Engineering
Casey Jowers (Author) - University of the Sunshine Coast - School of Science and Engineering
Michael Bermingham (Author) - University of Queensland
Tong Li (Author)
Justin Cooper-White (Author) - University of Queensland
Matthew S Dargusch (Author) - University of Queensland
Publication details: Journal of the Mechanical Behavior of Biomedical Materials, Vol.104, 103691
Publisher: Elsevier BV
Date published: 2020
DOI: 10.1016/j.jmbbm.2020.103691
ISSN: 1751-6161
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
Language: English
Record Identifier: 99450942802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Engineering, Biomedical; Materials Science, Biomaterials