Silica particles: A novel drug-delivery system

C J Barbé; John R Bartlett; L Kong; K S Finnie; H Q Lin; M Larkin; S Calleja; A J Bush; G Calleja

doi:10.1002/adma.200400771

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Silica particles: A novel drug-delivery system

Journal article

Peer reviewed

Silica particles: A novel drug-delivery system

C J Barbé, John R Bartlett, L Kong, K S Finnie, H Q Lin, M Larkin, S Calleja, A J Bush and G Calleja

Advanced Materials, Vol.16(21), pp.1959-1966

2004

DOI: https://doi.org/10.1002/adma.200400771

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Abstract

Physical Sciences

Chemical Sciences

Engineering

In recent decades, significant advances in drug-delivery systems have enabled more effective drug administration. To deliver drugs to specific organs, a range of organic systems (e.g., micelles, liposomes, and polymeric nanoparticles) have been designed. They suffer from limitations, including poor thermal and chemical stability, and rapid elimination by the immune system. In contrast, silica particles offer a biocompatible, stable, and "stealthy" alternative. Bioactive molecules can be easily encapsulated within silica particles by combining sol-gel polymerization with either spray-drying or emulsion chemistry. Spray-drying faces challenges, including low yield, surface segregation, and size limitations. In contrast, sol-gel emulsions enable the production of nanoparticles with homogeneous drug distribution, and permit ambient temperature processing, necessary for handling biologicals. Independent control of the size and release rate can be readily achieved. Preliminary in-vivo experiments reveal enhanced blood stability of the nanoparticles, which, coupled with sustained release of anti-tumor agents, show good potential for cancer treatment.

Details

Title: Silica particles: A novel drug-delivery system
Authors: C J Barbé (Author) - Australian Nuclear Science and Technology Organisation Materials Department
John R Bartlett (Author) - Australian Nuclear Science and Technology Organisation Materials Department
L Kong (Author) - Australian Nuclear Science and Technology Organisation Materials Department
K S Finnie (Author) - Australian Nuclear Science and Technology Organisation Materials Department
H Q Lin (Author) - Australian Nuclear Science and Technology Organisation Materials Department
M Larkin (Author) - Australian Nuclear Science and Technology Organisation Materials Department
S Calleja (Author) - Australian Nuclear Science and Technology Organisation Materials Department
A J Bush (Author) - Australian Nuclear Science and Technology Organisation Materials Department
G Calleja (Author) - Australian Nuclear Science and Technology Organisation Materials Department
Publication details: Advanced Materials, Vol.16(21), pp.1959-1966
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
Date published: 2004
DOI: 10.1002/adma.200400771
ISSN: 0935-9648
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99448969802621
Output Type: Journal article

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Web Of Science research areas: Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary; Nanoscience & Nanotechnology; Physics, Applied; Physics, Condensed Matter