Significance of LL-37 on Immunomodulation and Disease Outcome

Binbin Yang; David Good; Tamim Mosaiab; Wei Liu; Guoying Ni; Jasmine Kaur; Xiao Song Liu; Calvin Jessop; Lu Yang; Rushdi Fadhil; Zhengjun Yi; Ming Q Wei

doi:10.1155/2020/8349712

Back

Significance of LL-37 on Immunomodulation and Disease Outcome

Journal article

Open access

Peer reviewed

Significance of LL-37 on Immunomodulation and Disease Outcome

Binbin Yang, David Good, Tamim Mosaiab, Wei Liu, Guoying Ni, Jasmine Kaur, Xiao Song Liu, Calvin Jessop, Lu Yang, Rushdi Fadhil, …

BioMed Research International, Vol.2020, 8349712

2020

DOI: https://doi.org/10.1155/2020/8349712

Files and links (2)

pdf

PDF - Published Version (Open Access)1.01 MBDownload View

Published VersionPDF - Published Version (Open Access)CC BY V4.0, Open Access

url

https://doi.org/10.1155/2020/8349712View

Published Version

Abstract

LL-37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity. Recently, there have been increasing interest in its immune function. It was found that LL-37 can have two distinct functions in different tissues and different microenvironments. Thus, it is necessary to investigate LL-37 immune functions from the two sides of the same coin. On the one side, LL-37 promotes inflammation and immune response and exerts its anti-infective and antitumor effects; on the other side, it has the ability to inhibit inflammation and promote carcinogenesis. This review presents a brief summary of its expression, structure, and immunomodulatory effects as well as brief discussions on the role of this small peptide as a key factor in the development and treatment of various inflammation-related diseases and cancers.

Details

Title: Significance of LL-37 on Immunomodulation and Disease Outcome
Authors: Binbin Yang (Author) - Griffith University
David Good (Author) - Griffith University
Tamim Mosaiab (Author) - Griffith University
Wei Liu (Author) - Griffith University
Guoying Ni (Author) - University of the Sunshine Coast - School of Science and Engineering
Jasmine Kaur (Author) - Griffith University
Xiao Song Liu (Author) - University of the Sunshine Coast - School of Science and Engineering
Calvin Jessop (Author) - Griffith University
Lu Yang (Author) - Griffith University
Rushdi Fadhil (Author) - Griffith University
Zhengjun Yi (Author) - Weifang Medical University, China
Ming Q Wei (Author) - Griffith University
Publication details: BioMed Research International, Vol.2020, 8349712; 16
Publisher: Hindawi Publishing Corporation
Date published: 2020
DOI: 10.1155/2020/8349712
ISSN: 2314-6133
Copyright note: Copyright © 2020 Binbin Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy
Language: English
Record Identifier: 99450823002621
Output Type: Journal article

Metrics

4 File views/ downloads

43 Record Views

111 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biotechnology & Applied Microbiology; Medicine, Research & Experimental

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites