Journal article
Short-term exercise training early in life restores deficits in pancreatic beta-cell mass associated with growth restriction in adult male rats
American Journal of Physiology: Endocrinology and Metabolism, Vol.301(5), pp.E931-E940
2011
PMID: 21810930
Abstract
Short-term exercise training early in life restores deficits in pancreatic beta-cell mass associated with growth restriction in adult male rats. Am J Physiol Endocrinol Metab 301: E931-E940, 2011. First published August 2, 2011; doi: 10.1152/ajpendo.00114.2011.-Fetal growth restriction is associated with reduced pancreatic beta-cell mass, contributing to impaired glucose tolerance and diabetes. Exercise training increases beta-cell mass in animals with diabetes and has long-lasting metabolic benefits in rodents and humans. We studied the effect of exercise training on islet and beta-cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test ( IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted in Restricted offspring born small compared with shamoperated Controls and also sham-operated Reduced litter offspring that had their litter size reduced to five pups at birth. Restricted, Control, and Reduced litter offspring remained sedentary or underwent treadmill running from 5 to 9 or 20 to 24 wk of age. Early life exercise increased relative islet surface area and beta-cell mass across all groups at 9 wk, partially restoring the 60-68% deficit ( P < 0.05) in Restricted offspring. Remarkably, despite no further exercise training after 9 wk, beta-cell mass was restored in Restricted at 24 wk, while sedentary littermates retained a 45% deficit ( P < 0.05) in relative beta-cell mass. Later exercise training also restored Restricted beta-cell mass to Control levels. In conclusion, early life exercise training in rats born small restored beta-cell mass in adulthood and may have beneficial consequences for later metabolic health and disease.
Details
- Title
- Short-term exercise training early in life restores deficits in pancreatic beta-cell mass associated with growth restriction in adult male rats
- Authors
- Rhianna C. Laker (Author) - University of MelbourneLinda A. Gallo (Author) - University of MelbourneMary E. Wlodek (Corresponding Author) - University of MelbourneAndrew L. Siebel (Author) - Baker Heart and Diabetes InstituteGlenn D. Wadley (Author) - Deakin UniversityGlenn K. McConell (Author) - University of Melbourne
- Publication details
- American Journal of Physiology: Endocrinology and Metabolism, Vol.301(5), pp.E931-E940
- Publisher
- American Physiological Society
- DOI
- 10.1152/ajpendo.00114.2011
- ISSN
- 1522-1555
- PMID
- 21810930
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99679193102621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Endocrinology & Metabolism
- Physiology
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Source: InCites