Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses

C Chapman; N Tubridy; M J Cook; P J Mitchell; L R MacGregor; C Lovelock; Lucas Litewka; L Sedal; T J Kilpatrick; H Butzkueven

doi:10.1016/j.jocn.2005.08.012

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Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses

Journal article

Peer reviewed

Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses

C Chapman, N Tubridy, M J Cook, P J Mitchell, L R MacGregor, C Lovelock, Lucas Litewka, L Sedal, T J Kilpatrick and H Butzkueven

Journal of Clinical Neuroscience, Vol.13(6), pp.636-638

2006

DOI: https://doi.org/10.1016/j.jocn.2005.08.012

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Abstract

methylprednisolone

multiple sclerosis

cerebral atrophy

cerebral volume

We prospectively investigated the short-term effects of intravenous methyl-prednisolone (IVMP) on cerebral volume in patients suffering a multiple sclerosis (MS) relapse. Ten patients underwent MRI brain studies immediately before and after IVMP treatment, and 4 and 8 weeks later. Whole brain volumes decreased significantly over the 8-week period. The greatest change occurred during IVMP administration. This has implications for MS treatment trials using cerebral atrophy as an endpoint. © 2006 Elsevier Ltd. All rights reserved.

Details

Title: Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses
Authors: C Chapman (Author) - Royal Melbourne Hospital
N Tubridy (Author) - Royal Melbourne Hospital
M J Cook (Author) - St Vincent's Hospital
P J Mitchell (Author) - Royal Melbourne Hospital
L R MacGregor (Author) - Royal Melbourne Hospital
C Lovelock (Author) - Royal Melbourne Hospital
Lucas Litewka (Author) - St Vincent's Hospital
L Sedal (Author) - St Vincent's Hospital
T J Kilpatrick (Author) - St Vincent's Hospital
H Butzkueven (Author) - St Vincent's Hospital
Publication details: Journal of Clinical Neuroscience, Vol.13(6), pp.636-638
Publisher: Churchill Livingstone
Date published: 2006
DOI: 10.1016/j.jocn.2005.08.012
ISSN: 0967-5868
Organisation Unit: UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449255702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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