Short association fibres of the insula-temporoparietal junction in early psychosis: A diffusion tensor imaging study

S N Hatton; Jim Lagopoulos; Daniel F Hermens; I B Hickie; E Scott; Maxwell Bennett

doi:10.1371/journal.pone.0112842

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Short association fibres of the insula-temporoparietal junction in early psychosis: A diffusion tensor imaging study

Journal article

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Short association fibres of the insula-temporoparietal junction in early psychosis: A diffusion tensor imaging study

S N Hatton, Jim Lagopoulos, Daniel F Hermens, I B Hickie, E Scott and Maxwell Bennett

PLoS One, Vol.9(11), e112842

2014

DOI: https://doi.org/10.1371/journal.pone.0112842

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Abstract

Evidence shows that there are reductions in gray matter volume (GMV) and changes in long association white matter fibres within the left insula-temporoparietal junction (TPJ) during the early stages of psychotic disorders but less is known about short association fibres (sAFs). In this study we sought to characterise the changes in sAFs and associated volumetric changes of the left insula-TPJ during the early stages of psychosis. Magnetic resonance imaging was obtained from a sample of young people with psychosis (n = 42) and healthy controls (n = 45), and cortical parcellations of the left insula-TPJ were used as seeding masks to reconstruct 13 sAFs. Compared to healthy counterparts, the psychosis group showed significant reductions in fractional anisotropy (FA) in the sAFs connecting the superior (STG) and middle temporal gyri (MTG) and as well as reduced GMV within the inferior temporal gyrus and increased white matter volume (WMV) within Heschl's gyrus (HG). Furthermore, adolescent-onset psychosis subjects (onset 18 year or earlier) showed FA reductions in the STG-HG sAF when compared to adult-onset subjects, but this was not associated with changes in GMV nor WMV of the STG or HG. These findings suggest that during the early stages of psychosis, changes in sAFs and associated cortical GMV and WMV appear to occur independently, however age of onset of a psychotic syndrome/disorder influences the pattern of neuroanatomical abnormalities. © 2014 Hatton et al.

Details

Title: Short association fibres of the insula-temporoparietal junction in early psychosis: A diffusion tensor imaging study
Authors: S N Hatton (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
E Scott (Author) - University of Sydney
Maxwell Bennett (Author) - University of Sydney
Publication details: PLoS One, Vol.9(11), e112842
Publisher: Public Library of Science
Date published: 2014
DOI: 10.1371/journal.pone.0112842
ISSN: 1932-6203
Copyright note: Copyright © 2014 Hatton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449281002621
Output Type: Journal article

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