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Published VersionCC BY-NC-ND V4.0, Open
Journal article
Sex differences in fronto-limbic white matter tracts in youth with mood disorders
Psychiatry and Clinical Neurosciences, Vol.76(10), pp.481-489
2022
PMID: 35730893
Appears in Thompson Institute Research Collection
Abstract
Aims:
Depression and bipolar disorder patients have previously been shown to have impaired white matter (WM) integrity compared to healthy controls. This study aimed to investigate potential sex differences that may provide further insight into the pathophysiology of these highly debilitating mood disorders.
Methods:
Participants (17-30 years of age), N=168 depression (60% females) and N=107 bipolar disorder (74% females) and N=61 controls (64% females), completed clinical assessment, self-report measures and a neuropsychological assessment battery. Participants also underwent Magnetic Resonance Imaging scans from which Diffusion Tensor Imaging (DTI) data were collected across five fronto-limbic WM tracts: cingulum bundle (cingulate gyrus and hippocampus subsections), fornix, stria terminalis and the uncinate fasciculus (UF). Mean fractional anisotropy (FA) scores were compared between groups using analyses of variance with sex and diagnosis as fixed factors.
Results:
Among the nine WM tracts analysed, one revealed a significant interaction between sex and diagnosis, controlling for age. Male bipolar disorder patients had significantly lower FA scores in the fornix compared to the other groups. Furthermore, partial correlations revealed a significant positive association between FA scores for the fornix and psychomotor speed.
Conclusions:
Our findings suggest that males with bipolar disorder may be at increased risk of disruptions in WM integrity, especially in the fornix, which is thought to be responsible for a range of cognitive functions. More broadly, our findings suggest that sex differences may exist in WM integrity and thereby alter our understanding of the pathophysiology of mood disorders.
Details
- Title
- Sex differences in fronto-limbic white matter tracts in youth with mood disorders
- Authors
- Daniel Hermens (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel Jamieson (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteLauren Fitzpatrick (Author) - The University of SydneyDashiell Sacks (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteFrank Iorfino (Author) - The University of SydneyJacob J Crouse (Author) - The University of SydneyAdam J Guastella (Author) - The University of SydneyElizabeth M Scott (Author) - The University of SydneyIan B Hickie (Author) - The University of SydneyJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Psychiatry and Clinical Neurosciences, Vol.76(10), pp.481-489
- Publisher
- John Wiley & Sons, Inc.
- Date published
- 2022
- DOI
- 10.1111/pcn.13440
- ISSN
- 1440-1819; 1323-1316
- PMID
- 35730893
- Copyright note
- This is the peer reviewed version of the following article: Hermens, D.F., Jamieson, D., Fitzpatrick, L., Sacks, D.D., Iorfino, F., Crouse, J.J., Guastella, A.J., Scott, E.M., Hickie, I.B. and Lagopoulos, J. (2022), Sex differences in fronto-limbic white matter tracts in youth with mood disorders. Psychiatry Clin. Neurosci.. Accepted Author Manuscript. https://doi.org/10.1111/pcn.13440, which has been published in final form at https://doi.org/10.1111/pcn.13440. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
- Grants
- Grant note
- NHMRC Australia Fellowship (No. 511921 awarded to I.B.H.).
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 99649177802621
- Output Type
- Journal article
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