Files and links (1)
Published VersionCC BY V4.0, Open Access
Journal article
Sex-Specific Changes to Brain Fatty Acids, Plasmalogen, and Plasma Endocannabinoids in Offspring Exposed to Maternal and Postnatal High-Linoleic-Acid Diets
International Journal of Molecular Sciences, Vol.25(14), pp.1-16
2024
Abstract
Linoleic acid (LA) is required for neuronal development. We have previously demonstrated sex-specific changes in cardiovascular and hepatic function in rat offspring from mothers consuming a high-LA diet, with some effects associated with reduced LA concentration in the postnatal diet. At this time, the impact of a high-maternal-LA diet on offspring brain development and the potential for the postnatal diet to alter any adverse changes are unknown. Rat offspring from mothers fed low- (LLA) or high-LA (HLA) diets during pregnancy and lactation were weaned at postnatal day 25 (PN25) and fed LLA or HLA diets until sacrifice in adulthood (PN180). In the offspring’s brains, the postnatal HLA diet increased docosapentaenoate in males. The maternal HLA diet increased LA, arachidonate, docosapentaenoate, C18:0 dimethylacetal (DMA), C16:0 DMA, C16:0 DMA/C16:0, and C18:0 DMA/C18:0, but decreased eoicosenoate, nervoniate, lignocerate, and oleate in males. Maternal and postnatal HLA diets reduced oleate and vaccenate and had an interaction effect on myristate, palmitoleate, and eicosapentaenoate in males. In females, maternal HLA diet increased eicosadienoate. Postnatal HLA diet increased stearate and docosapentaenoate. Maternal and postnatal HLA diets had an interaction effect on oleate, arachidate, and docosahexaenoic acid (DHA)/omega (n)-6 docosapentaenoic acid (DPA) in females. Postnatal HLA diet decreased DHA/n-6 DPA in males and females. Postnatal HLA diet increased plasma endocannabinoids (arachidonoyl ethanolamide and 2-arachidonoyl glycerol), as well as other N-acyl ethanolamides and testosterone. HLA diet alters brain fatty acids, plasma endocannabinoids, and plasmalogen concentrations in a development-specific and sex-specific manner.
Details
- Title
- Sex-Specific Changes to Brain Fatty Acids, Plasmalogen, and Plasma Endocannabinoids in Offspring Exposed to Maternal and Postnatal High-Linoleic-Acid Diets
- Authors
- Henry C. Ezechukwu - The University of Western AustraliaLuke J. Ney - Queensland University of TechnologyMadeline A. Jarvis - Queensland University of TechnologyNirajan Shrestha - Griffith UniversityOlivia J. Holland - Griffith UniversityJames S. M. Cuffe - The University of QueenslandAnthony V. Perkins - University of the Sunshine Coast, Queensland, School of HealthSuk-Yu Yau - Hong Kong Polytechnic UniversityAndrew J. McAinch - Victoria UniversityDeanne H. Hryciw (Corresponding Author) - Griffith University
- Publication details
- International Journal of Molecular Sciences, Vol.25(14), pp.1-16
- Publisher
- MDPI AG
- Date published
- 2024
- DOI
- 10.3390/ijms25147911
- ISSN
- 1422-0067; 1661-6596
- Copyright note
- © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Data Availability
- The raw data supporting the conclusions of this article will be made available by the authors on request.
- Grant note
- This work was supported by the Allen Foundation (USA).
- Organisation Unit
- School of Health - Biomedicine; School of Health
- Language
- English
- Record Identifier
- 991048852102621
- Output Type
- Journal article
Metrics
22 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites