Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Z Kote-Jarai; A A A Olama; G G Giles; G Severi; J Schleutker; M Weischer; D Campa; E Riboli; T Key; H Gronberg; D J Hunter; P Kraft; M J Thun; S Ingles; S Chanock; D Albanes; R B Hayes; D E Neal; F C Hamdy; Jenny L Donovan; P Pharoah; F Schumacher; B E Henderson; J L Stanford; E A Ostrander; K D Sorensen; T Dörk; G Andriole; J L Dickinson; C Cybulski; J Lubinski; A Spurdle; J A Clements; S Chambers; J Aitken; R A F Gardiner; S N Thibodeau; D Schaid; E M John; C Maier; W Vogel; K A Cooney; J Y Park; L Cannon-Albright; H Brenner; T Habuchi; H W Zhang; Y J Lu; R Kaneva; K Muir; S Benlloch; D A Leongamornlert; E J Saunders; M Tymrakiewicz; N Mahmud; M Guy; L T O'Brien; R A Wilkinson; A L Hall; E J Sawyer; T Dadaev; J Morrison; D P Dearnaley; A Horwich; R A Huddart; V S Khoo; C C Parker; N Van As; C J Woodhouse; A Thompson; T Christmas; C Ogden; C S Cooper; A Lophatonanon; M C Southey; J L Hopper; D R English; T Wahlfors; T L J Tammela; P Klarskov; B G Nordestgaard; M A Røder; A Tybjarg-Hansen; S E Bojesen; R Travis; F Canzian; R Kaaks; F Wiklund; M Aly; S Lindstrom; W R Diver; S Gapstur; M C Stern; R Corral; J Virtamo; A Cox; C A Haiman; L Le Marchand; L Fitzgerald; S Kolb; E M Kwon; D M Karyadi; T F Ørntoft; M Borre; A Meyer; J Serth; M Yeager; S I Berndt; J R Marthick; B Patterson; D Wokolorczyk; J Batra; Felicity Lose; S K McDonnell; A D Joshi; A Shahabi; A E Rinckleb; A Ray; T A Sellers; H Y Lin; R A Stephenson; J Farnham; H Muller; D Rothenbacher; N Tsuchiya; S Narita; G W Cao; C Slavov; V Mitev; D F Easton; R A Eeles

doi:10.1038/ng.882

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Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

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Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

Z Kote-Jarai, A A A Olama, G G Giles, G Severi, J Schleutker, M Weischer, D Campa, E Riboli, T Key, H Gronberg, …

Nature Genetics, Vol.43(8), pp.785-791

2011

DOI: https://doi.org/10.1038/ng.882

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Abstract

Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10-8 to P = 2.7 × 10-24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining 425% of the familial risk in this disease, have now been identified. © 2011 Nature America, Inc. All rights reserved.

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Title: Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
Authors: Z Kote-Jarai (Author)
A A A Olama (Author)
G G Giles (Author)
G Severi (Author)
J Schleutker (Author)
M Weischer (Author)
D Campa (Author)
E Riboli (Author)
T Key (Author)
H Gronberg (Author)
D J Hunter (Author)
P Kraft (Author)
M J Thun (Author)
S Ingles (Author)
S Chanock (Author)
D Albanes (Author)
R B Hayes (Author)
D E Neal (Author)
F C Hamdy (Author)
Jenny L Donovan (Author)
P Pharoah (Author)
F Schumacher (Author)
B E Henderson (Author)
J L Stanford (Author)
E A Ostrander (Author)
K D Sorensen (Author)
T Dörk (Author)
G Andriole (Author)
J L Dickinson (Author)
C Cybulski (Author)
J Lubinski (Author)
A Spurdle (Author)
J A Clements (Author)
S Chambers (Author)
J Aitken (Author)
R A F Gardiner (Author)
S N Thibodeau (Author)
D Schaid (Author)
E M John (Author)
C Maier (Author)
W Vogel (Author)
K A Cooney (Author)
J Y Park (Author)
L Cannon-Albright (Author)
H Brenner (Author)
T Habuchi (Author)
H W Zhang (Author)
Y J Lu (Author)
R Kaneva (Author)
K Muir (Author)
S Benlloch (Author)
D A Leongamornlert (Author)
E J Saunders (Author)
M Tymrakiewicz (Author)
N Mahmud (Author)
M Guy (Author)
L T O'Brien (Author)
R A Wilkinson (Author)
A L Hall (Author)
E J Sawyer (Author)
T Dadaev (Author)
J Morrison (Author)
D P Dearnaley (Author)
A Horwich (Author)
R A Huddart (Author)
V S Khoo (Author)
C C Parker (Author)
N Van As (Author)
C J Woodhouse (Author)
A Thompson (Author)
T Christmas (Author)
C Ogden (Author)
C S Cooper (Author)
A Lophatonanon (Author)
M C Southey (Author)
J L Hopper (Author)
D R English (Author)
T Wahlfors (Author)
T L J Tammela (Author)
P Klarskov (Author)
B G Nordestgaard (Author)
M A Røder (Author)
A Tybjarg-Hansen (Author)
S E Bojesen (Author)
R Travis (Author)
F Canzian (Author)
R Kaaks (Author)
F Wiklund (Author)
M Aly (Author)
S Lindstrom (Author)
W R Diver (Author)
S Gapstur (Author)
M C Stern (Author)
R Corral (Author)
J Virtamo (Author)
A Cox (Author)
C A Haiman (Author)
L Le Marchand (Author)
L Fitzgerald (Author)
S Kolb (Author)
E M Kwon (Author)
D M Karyadi (Author)
T F Ørntoft (Author)
M Borre (Author)
A Meyer (Author)
J Serth (Author)
M Yeager (Author)
S I Berndt (Author)
J R Marthick (Author)
B Patterson (Author)
D Wokolorczyk (Author)
J Batra (Author)
Felicity Lose (Author) - Queensland Institute of Medical Research
S K McDonnell (Author)
A D Joshi (Author)
A Shahabi (Author)
A E Rinckleb (Author)
A Ray (Author)
T A Sellers (Author)
H Y Lin (Author)
R A Stephenson (Author)
J Farnham (Author)
H Muller (Author)
D Rothenbacher (Author)
N Tsuchiya (Author)
S Narita (Author)
G W Cao (Author)
C Slavov (Author)
V Mitev (Author)
D F Easton (Author)
R A Eeles (Author)
Publication details: Nature Genetics, Vol.43(8), pp.785-791
Publisher: Nature Publishing Group
Date published: 2011
DOI: 10.1038/ng.882
ISSN: 1061-4036
Copyright note: Copyright © 2011 Nature Publishing Group. The accepted version is reproduced here in accordance with the publishers copyright policy. The definitive version is available from https://www.nature.com/ng/
Organisation Unit: University of the Sunshine Coast, Queensland; Office of Research
Language: English
Record Identifier: 99451176602621
Output Type: Journal article

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