Journal article
Seven-day remote ischemic preconditioning improves local and systemic endothelial function and microcirculation in healthy humans
American Journal of Hypertension, Vol.27(7), pp.918-925
2014
Abstract
BACKGROUND Ischemic preconditioning (IPC) protects tissue against ischemia-induced injury inside and outside ischemic areas. The purpose was to examine the hypothesis that daily IPC leads to improvement in endothelial function and skin microcirculation not only in the arm exposed to IPC but also in the contralateral arm. METHODS Thirteen healthy, young, normotensive male individuals (aged 22±2 years) were assigned to 7-day daily exposure of the arm to IPC (4×5 minutes). Assessment of brachial artery endothelial function (using flow-mediated dilation (FMD)) and forearm microcirculation (cutaneous vascular conductance (CVC) at baseline and during local heating) was performed before and after 7 days to examine the local (i.e., intervention arm) and remote (i.e., control arm) effect of IPC. We repeated the assessment tests 8 days after the intervention (Post+8). RESULTS FMD increased after repeated IPC (P = 0.03) and remained significantly elevated at Post+8 in the intervention (5.0±2.2%, 6.1±2.2%, and 6.6±2.3%) and contralateral arms (5.4±2.2%, 6.0±2.2%, and 7.5±2.2%). Forearm CVC also increased following repeated IPC (P = 0.006) and remained elevated at Post+8 in both arms (intervention: 0.12±0.03, 0.14±0.04, 0.16±0.04 mV/mm Hg; contralateral: 0.14±0.04, 0.015±0.04, 0.17±0.07). No interaction between IPC arm and time was evident for FMD and CVC (both P > 0.05). IPC intervention did not alter CVC responses to local heating (P > 0.05). CONCLUSIONS Daily exposure to IPC for 7 days leads to local and remote improvements in brachial artery FMD and resting skin microcirculation that remain after cessation of the intervention and beyond the late phase of protection. These findings may have clinical relevance for micro-and macrovascular improvements. © 2014 American Journal of Hypertension, Ltd.
Details
- Title
- Seven-day remote ischemic preconditioning improves local and systemic endothelial function and microcirculation in healthy humans
- Authors
- H Jones (Author) - Liverpool John Moores University, United KingdomN Hopkins (Author) - Liverpool John Moores University, United KingdomTom G Bailey (Author) - Liverpool John Moores University, United KingdomD J Green (Author) - Liverpool John Moores University, United KingdomN Timothy Cable (Author) - Liverpool John Moores University, United KingdomD H J Thijssen (Author) - Liverpool John Moores University, United Kingdom
- Publication details
- American Journal of Hypertension, Vol.27(7), pp.918-925
- Publisher
- Oxford University Press
- Date published
- 2014
- DOI
- 10.1093/ajh/hpu004
- ISSN
- 0895-7061
- Organisation Unit
- UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99450194402621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
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- Peripheral Vascular Disease
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Source: InCites