Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study

Elisabeth A Isenring; Laisa Teleni; Richard J Woodman; Michael G Kimlin; Euan Walpole; Christos S Karapetis; Shawgi Shawgi; Ganessan Kichenadasse; Skye Marshall; Bogda Koczwara

doi:10.6133/apjcn.042018.01

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Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study

Journal article

Peer reviewed

Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study

Elisabeth A Isenring, Laisa Teleni, Richard J Woodman, Michael G Kimlin, Euan Walpole, Christos S Karapetis, Shawgi Shawgi, Ganessan Kichenadasse, Skye Marshall and Bogda Koczwara

Asia Pacific Journal of Clinical Nutrition, Vol.27(5), pp.962-967

2018

DOI: https://doi.org/10.6133/apjcn.042018.01

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Abstract

vitamin D

25(OH) D

cancer

chemotherapy

breast cancer

Background and Objectives: Vitamin D plays an important role in bone and muscle function, and cell proliferation. The impact of chemotherapy and associated behavioural changes such as fatigue and sun avoidance on vitamin D (25(OH) D) is unknown. This study aims to evaluate variations in serum vitamin D during chemotherapy and the predictive value of latitude, season and pre-existing vitamin D deficiency. Methods and Study Design: A 12-week prospective cohort study was conducted in chemotherapy-naive patients in two Australian locations with different sun exposure. Vitamin D deficiency was defined as <25 nmol/L and insufficiency 26-50 nmol/L 25(OH) D. Demographics, chemotherapy regimen, nutritional status, sun exposure, geographic location, and season were collected at baseline, 6 and 12 weeks after commencing chemotherapy. Results: Eighty-five patients (p55.3±13.4 years of age; 49% female) were recruited. 96% Caucasian. Fifty-four patients were treated with curative intent (mostly for breast [n=29] or colorectal [n= 12] cancers). At baseline. 10 patients were vitamin D deficient and 33 were insufficient. Mean serum 25(OH) D (nmol/L) was higher at latitude -27.5° (Brisbane) than latitude -34.9° (Adelaide) (p61.9±22.1 vs p42.2±19.2, (P<0.001) and varied according to season (spring: p46.9±20.3, summer: p50.8±l8.2. autumn: p76.4±25.2. winter: p36.5±15.7, p<0.001). Serum 25(OH) D decreased with chemotherapy (baseline: p49.2±22.3. 6-weeks: p40.9±19.0. 12-weeks: p45.9±19.7. (P=0.05). with a significant and more rapid decline in winter and autumn (P-0.03). Conclusions: Chemotherapy is associated with a decrease in serum vitamin D. particularly during winter and autumn. Investigations into the underlying mechanism and associated potential outcomes with this decrease requires further investigation.

Details

Title: Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study
Authors: Elisabeth A Isenring (Author)
Laisa Teleni (Author)
Richard J Woodman (Author)
Michael G Kimlin (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Euan Walpole (Author)
Christos S Karapetis (Author)
Shawgi Shawgi (Author)
Ganessan Kichenadasse (Author)
Skye Marshall (Author)
Bogda Koczwara (Author)
Publication details: Asia Pacific Journal of Clinical Nutrition, Vol.27(5), pp.962-967
Publisher: H E C Press
Date published: 2018
DOI: 10.6133/apjcn.042018.01
ISSN: 0964-7058
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99451220302621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Nutrition & Dietetics

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