Journal article
Seroprevalence of Q fever among metropolitan and non-metropolitan blood donors in New South Wales and Queensland, 2014–2015
Medical Journal of Australia, Vol.210(7), pp.309-315
2019
Abstract
Objectives: To estimate the prevalence of exposure to the causative agent of Q fever (Coxiella burnetii) and of current infections among blood donors in Australia. Design, setting: Cross-sectional study in metropolitan Sydney and Brisbane, and in non-metropolitan regions with high Q fever notification rates (Hunter New England in New South Wales; Toowoomba in Queensland). Participants: Blood donors attending Red Cross collection centres during October 2014 - June 2015 who provided sera and completed a questionnaire on Q fever vaccination status, diagnosis and knowledge, and exposure history. Main outcome measures: Age- and sex-standardised seroprevalence of phase II IgG antibodies to C. burnetii (indicating past exposure) and independent risk factors for seropositivity; presence of C. burnetii DNA (indicating current infection and risk of transmission by blood transfusion). Results: 2740 donors (94.5% response rate) completed the questionnaire and supplied sera for analysis. Crude antibody seroprevalence was 3.6%. Standardised seroprevalence was higher in non-metropolitan than metropolitan regions (NSW, 3.7% v 2.8%; Queensland, 4.9% v 1.6%; statistically significant only in Queensland). Independent predictors of antibody seropositivity were regular contact with sheep, cattle, or goats (adjusted odds ratio [aOR], 5.3; 95% CI, 2.1-14), abattoir work (aOR, 2.2; 95% CI, 1.2-3.9), and assisting at an animal birth (aOR, 2.1; 95% CI, 1.2-3.6). Having lived in a rural area but having only rare or no contact with sheep, cattle or goats was itself a significant risk factor (v never lived rurally: aOR, 2.5; 95% CI, 1.1-5.9). 40% of people in groups recommended for vaccination were aware of the vaccine; 10% of people in these groups had been vaccinated. C. burnetii DNA was not detected in 1681 non-metropolitan samples, suggesting that transmission by blood donation is unlikely. Conclusions: Given their exposure to multiple risk factors, vaccination against Q fever should be considered for all rural residents.
Details
- Title
- Seroprevalence of Q fever among metropolitan and non-metropolitan blood donors in New South Wales and Queensland, 2014–2015
- Authors
- Heather F Gidding (Corresponding Author) - The University of SydneyHelen M Faddy (Author) - Australian Red Cross Blood ServiceDavid N Durrheim (Author) - University of Newcastle AustraliaStephen R Graves (Author) - Geelong HospitalChelsea Nguyen (Author) - Geelong HospitalPenny Hutchinson (Author) - Darling Downs Public Health UnitPeter Massey (Author) - Hunter New England Local Health DistrictNicholas Wood (Author) - The University of Sydney
- Publication details
- Medical Journal of Australia, Vol.210(7), pp.309-315
- Publisher
- Wiley-Blackwell Publishing Asia
- Date published
- 2019
- DOI
- 10.5694/mja2.13004
- ISSN
- 0025-729X
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99450795502621
- Output Type
- Journal article
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