Sero-epidemiological assessment of Chlamydia trachomatis infection and sub-fertility in Samoan women

S Menon; S H Stansfield; M Walsh; E Hope; L Isaia; A A Righars; T Niupulusu; S V A Temese; L Iosefa-Siitia; L Auvaa; S A Tapelu; M F Motu; T Suaalii-Sauni; Peter Timms; P C Hill; W M Huston

doi:10.1186/s12879-016-1508-0

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Sero-epidemiological assessment of Chlamydia trachomatis infection and sub-fertility in Samoan women

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Sero-epidemiological assessment of Chlamydia trachomatis infection and sub-fertility in Samoan women

S Menon, S H Stansfield, M Walsh, E Hope, L Isaia, A A Righars, T Niupulusu, S V A Temese, L Iosefa-Siitia, L Auvaa, …

BMC Infectious Diseases, Vol.16, 175

2016

DOI: https://doi.org/10.1186/s12879-016-1508-0

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Abstract

chlamydia

Pacific Islands

Samoa

female sub-fertility

diagnosis

serology

Background: In our recent village-based cross-sectional study, the prevalence of nucleic acid amplification technique (NAAT) diagnosed Chlamydia trachomatis (CT) in sexually active Samoan women was very high (36 %), and test positivity was associated with sub-fertility. We conducted a serological and epidemiological analysis in these participants to identify if serological data can provide further insight into the potential contribution of CT to sub-fertility in this population. Methods: Serological prediction of CT associated sub-fertility was conducted using a series of commercial tests. The correlation between fertility or sub-fertility, behavioral factors, and serologically predicted CT associated subfertility was determined. Results: A positive antibody reaction against the Chlamydia Major Outer Membrane Protein (MOMP) was significantly associated with sub-fertility, with 50 % of infertile women being positive. Serum IgG and IgA antibodies against MOMP correlated with current infection measured by urine NAAT, suggesting longer term infections are common in this population. Chlamydia pneumoniae antibodies were frequently detected in this population (84 %), and unexpectedly, were significantly associated with sub-fertility. Conclusions: The high prevalence of chlamydial infection and of positive chlamydial sub-fertility results suggests that CT is an important and frequent contributory factor to sub-fertility in this population.

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Title: Sero-epidemiological assessment of Chlamydia trachomatis infection and sub-fertility in Samoan women
Authors: S Menon (Author) - Queensland University of Technology
S H Stansfield (Author) - Queensland University of Technology
M Walsh (Author) - University of Otago, New Zealand
E Hope (Author) - National University of Samoa, Samoa
L Isaia (Author) - National Health Service Laboratory Division
A A Righars (Author) - University of Otago, New Zealand
T Niupulusu (Author) - Samoa Family Health Assocation, Samoa
S V A Temese (Author) - University of Samoa, Samoa
L Iosefa-Siitia (Author) - Samoa National Council for Churches, Samoa
L Auvaa (Author) - National University of Samoa, Samoa
S A Tapelu (Author) - Samoa AIDS Foundation, Samoa
M F Motu (Author) - Samoa National Council for Churches, Samoa
T Suaalii-Sauni (Author) - Victoria University of Wellington, New Zealand
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
P C Hill (Author) - University of Otago, New Zealand
W M Huston (Author) - Queensland University of Technology
Publication details: BMC Infectious Diseases, Vol.16, 175; 7
Publisher: BioMed Central Ltd.
Date published: 2016
DOI: 10.1186/s12879-016-1508-0
ISSN: 1471-2334
Copyright note: Copyright © 2016 Menon et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449719402621
Output Type: Journal article

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