Serial MRI in multiple sclerosis: A prospective pilot study of lesion load, whole brain volume and thalamic atrophy

I Taylor; H Butzkueven; Lucas Litewka; L R MacGregor; C Szoeke; M Cook; P Mitchell; T J Kilpatrick; N Tubridy

doi:10.1016/S0967-5868(03)00145-0

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Serial MRI in multiple sclerosis: A prospective pilot study of lesion load, whole brain volume and thalamic atrophy

Journal article

Peer reviewed

Serial MRI in multiple sclerosis: A prospective pilot study of lesion load, whole brain volume and thalamic atrophy

I Taylor, H Butzkueven, Lucas Litewka, L R MacGregor, C Szoeke, M Cook, P Mitchell, T J Kilpatrick and N Tubridy

Journal of Clinical Neuroscience, Vol.11(2), pp.153-158

2004

DOI: https://doi.org/10.1016/S0967-5868(03)00145-0

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Abstract

magnetic resonance imaging

multiple sclerosis

thalamic volume

atrophy

Using serial magnetic resonance imaging (MRI), we investigated the relationship between diffuse cerebral atrophy, T1 and T2 lesion volumes, mean thalamic volumes and clinical progression in patients with established multiple sclerosis (MS). Eleven patients were included in this prospective serial study. Cerebral volumes, T1 hypointense lesion volumes, and T2 hyperintense lesion volumes at baseline and at up to 3 years follow-up were assessed on MRI brain scans. As a putative measure of cerebral atrophy mean thalamic volumes were also obtained. The outcome measures were the MRI parameters and disability on Kurtzke's expanded disability status scale (EDSS). Of the 11 patients 6 worsened clinically as measured by an increase of 0.5 or more on the EDSS. Cerebral atrophy occurred in 91% of patients and was independent of changes in lesion volumes and was not associated with disease progression as determined by the EDSS. © 2003 Elsevier Ltd. All rights reserved.

Details

Title: Serial MRI in multiple sclerosis: A prospective pilot study of lesion load, whole brain volume and thalamic atrophy
Authors: I Taylor (Author) - Royal Melbourne Hospital
H Butzkueven (Author) - Royal Melbourne Hospital
Lucas Litewka (Author) - St Vincent's Hospital Melbourne
L R MacGregor (Author) - Royal Melbourne Hospital
C Szoeke (Author) - Royal Melbourne Hospital
M Cook (Author) - St Vincent's Hospital Melbourne
P Mitchell (Author) - Royal Melbourne Hospital
T J Kilpatrick (Author) - Royal Melbourne Hospital
N Tubridy (Author) - Royal Melbourne Hospital
Publication details: Journal of Clinical Neuroscience, Vol.11(2), pp.153-158
Publisher: Churchill Livingstone
Date published: 2004
DOI: 10.1016/S0967-5868(03)00145-0
ISSN: 0967-5868
Organisation Unit: UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449343002621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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