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Selenoproteins in the Human Placenta - How Essential Is Selenium to a Healthy Start to Life933.65 kB
Published VersionCC BY V4.0, Open Access
Journal article
Selenoproteins in the Human Placenta: How Essential Is Selenium to a Healthy Start to Life?
Nutrients, Vol.14(3), pp.1-18
2022
PMID: 35276987
Abstract
Selenium is an essential trace element required for human health, and selenium deficiency has been associated with many diseases. The daily recommended intake of selenium is 60 mu g/day for adults, which increases to 65 mu g/day for women when pregnant. Selenium is incorporated into the 21st amino acid, selenocysteine (sec), a critical component of selenoproteins that plays an important role in a variety of biological responses such as antioxidant defence, reactive oxygen species (ROS) signalling, formation of thyroid hormones, DNA synthesis and the unfolded protein response in the endoplasmic reticulum (ER). Although 25 selenoproteins have been identified, the role of many of these is yet to be fully characterised. This review summarises the current evidence demonstrating that selenium is essential for a healthy pregnancy and that poor selenium status leads to gestational disorders. In particular, we focus on the importance of the placental selenoproteome, and the role these proteins may play in a healthy start to life.
Details
- Title
- Selenoproteins in the Human Placenta: How Essential Is Selenium to a Healthy Start to Life?
- Authors
- Claire Hogan (Author) - Griffith UniversityAnthony V. Perkins (Corresponding Author) - Griffith University
- Publication details
- Nutrients, Vol.14(3), pp.1-18
- Publisher
- MDPI AG
- Date published
- 2022
- DOI
- 10.3390/nu14030628
- ISSN
- 2072-6643
- PMID
- 35276987
- Copyright note
- © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685196302621
- Output Type
- Journal article
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