Journal article
Selenium supplementation induces mitochondrial biogenesis in trophoblasts
Placenta, Vol.36(8), pp.863-869
2015
PMID: 26154583
Abstract
Introduction: Placental oxidative stress has been implicated in pregnancy complications and previous work has shown that selenium can protect trophoblast mitochondria from oxidative stress. This report examines mitochondrial function and content in trophoblasts supplemented with selenium.
Methods: Swan-71, JEG-3 and BeWo cells and placental tissue were incubated with sodium selenite or selenomethionine. Mitochondrial function was examined in a respirometer. Mitochondrial content was determined using RT-PCR. The levels of the mitochondrial biogenesis markers selenoprotein H, PGC-l alpha and NRF-1 was examined by western blotting.
Results: Mitochondrial respiration was significantly enhanced post selenium supplementation in cells and tissues. Selenium supplementation increased mitochondrial content and up-regulated mitochondrial biogenesis mediators in cells.
Discussion: These results emphasise the importance of selenium in mitochondrial regeneration in trophoblasts.
Details
- Title
- Selenium supplementation induces mitochondrial biogenesis in trophoblasts
- Authors
- Alisha Khera (Author) - Griffith UniversityLan-feng Dong (Author) - Griffith UniversityOlivia Holland (Corresponding Author) - Griffith UniversityJessica Vanderlelie (Author) - Griffith UniversityElham A. Pasdar (Author) - Griffith UniversityJiri Neuzil (Author) - Griffith UniversityAnthony V. Perkins (Author) - Griffith University
- Publication details
- Placenta, Vol.36(8), pp.863-869
- Publisher
- Elsevier Ltd.
- DOI
- 10.1016/j.placenta.2015.06.010
- ISSN
- 1532-3102
- PMID
- 26154583
- Grant note
- Griffith University School of Medical Science Postgraduate Research Account
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
- Language
- English
- Record Identifier
- 99685293502621
- Output Type
- Journal article
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- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Developmental Biology
- Obstetrics & Gynecology
- Reproductive Biology
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Source: InCites