Selenium status in UK pregnant women and its relationship with hypertensive conditions of pregnancy

Margaret P. Rayman; Sarah C. Bath; Jacob Westaway; Peter Williams; Jinyuan Mao; Jessica J. Vanderlelie; Anthony V. Perkins; Christopher W. G. Redman

doi:10.1017/S000711451400364X

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Selenium status in UK pregnant women and its relationship with hypertensive conditions of pregnancy

Journal article

Open access

Peer reviewed

Selenium status in UK pregnant women and its relationship with hypertensive conditions of pregnancy

Margaret P. Rayman, Sarah C. Bath, Jacob Westaway, Peter Williams, Jinyuan Mao, Jessica J. Vanderlelie, Anthony V. Perkins and Christopher W. G. Redman

British Journal of Nutrition, Vol.113(2), pp.249-258

2015

DOI: https://doi.org/10.1017/S000711451400364X

PMCID: PMC4302388

PMID: 25571960

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Abstract

selenium status

pregnancy

hypertension

hypertensive conditions of pregnancy

Dietary intake/status of the trace mineral Se may affect the risk of developing hypertensive conditions of pregnancy, i.e. pre-eclampsia and pregnancy-induced hypertension (PE/PIH). In the present study, we evaluated Se status in UK pregnant women to establish whether pre-pregnant Se status or Se supplementation affected the risk of developing PE/PIH. The samples originated from the SPRINT (Selenium in PRegnancy INTervention) study that randomised 230 UK primiparous women to treatment with Se (60 mu g/d) or placebo from 12 weeks of gestation. Whole-blood Se concentration was measured at 12 and 35 weeks, toenail Se concentration at 16 weeks, plasma selenoprotein P (SEPP1) concentration at 35 weeks and plasma glutathione peroxidase (GPx3) activity at 12, 20 and 35 weeks. Demographic data were collected at baseline. Participants completed a FFQ. UK pregnant women had whole-blood Se concentration lower than the mid-range of other populations, toenail Se concentration considerably lower than US women, GPx3 activity considerably lower than US and Australian pregnant women, and low baseline SEPP1 concentration (median 3.00, range 0.90-5.80 mg/l). Maternal age, education and social class were positively associated with Se status. After adjustment, whole-blood Se concentration was higher in women consuming Brazil nuts (P = 0.040) and in those consuming more than two seafood portions per week (P = 0.054). A stepwise logistic regression model revealed that among the Se-related risk factors, only toenail Se (OR 0.38, 95% CI 0.17, 0.87, P = 0.021) significantly affected the OR for PE/PIH. On excluding non-compliers with Se treatment, Se supplementation also significantly reduced the OR for PE/PIH (OR 0.30, 95% CI 0.09, 1.00, P = 0.049). In conclusion, UK women have low Se status that increases their risk of developing PE/PIH. Therefore, UK women of childbearing age need to improve their Se status.

Details

Title: Selenium status in UK pregnant women and its relationship with hypertensive conditions of pregnancy
Authors: Margaret P. Rayman (Corresponding Author) - University of Surrey
Sarah C. Bath (Author) - University of Surrey
Jacob Westaway (Author) - Griffith University
Peter Williams (Author) - University of Surrey
Jinyuan Mao (Author) - University of Surrey
Jessica J. Vanderlelie (Author) - Griffith University
Anthony V. Perkins (Author) - Griffith University
Christopher W. G. Redman (Author) - University of Oxford
Publication details: British Journal of Nutrition, Vol.113(2), pp.249-258
Publisher: Cambridge University Press
Date published: 2015
DOI: 10.1017/S000711451400364X
ISSN: 1475-2662; 0007-1145
PMID: 25571960; PMC4302388
Copyright note: q The Authors 2015. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Grant note: NIH ES02497 / SEPP1 analyses at the laboratory of Raymond Burk, University of Vanderbilt MRC Population Health Scientist Fellowship; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) R01ES002497 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) MR/K02132X/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission 083918/Z/07/Z / Wellcome Trust; European Commission MR/K02132X/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 283883 / European Commission under the 7th Framework Programme through the 'Research Infrastructures' action of the 'Capacities' Programme (NMI3-II) Nestle Nutrition Institute Fellowship; Nestle SA
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99685295702621
Output Type: Journal article

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