Files and links (2)
Selenium Prevents Inflammation in Human Placenta and Adipose Tissue In Vitro - Implications for Metabolic Diseases of Pregnancy Associated with Inflammation4.74 MB
Published VersionCC BY V4.0, Open Access
Journal article
Selenium Prevents Inflammation in Human Placenta and Adipose Tissue In Vitro: Implications for Metabolic Diseases of Pregnancy Associated with Inflammation
Nutrients, Vol.14(16), pp.1-19
2022
PMID: 36014792
Abstract
Gestational diabetes mellitus (GDM) and maternal obesity are significant metabolic complications increasingly prevalent in pregnancy. Of major concern, both GDM and maternal obesity can have long-term detrimental impacts on the health of both mother and offspring. Recent research has shown that increased inflammation and oxidative stress are two features central to the pathophysiology of these metabolic conditions. Evidence suggests selenium supplementation may be linked to disease prevention in pregnancy; however, the specific effects of selenium on inflammation and oxidative stress associated with GDM and maternal obesity are unknown. Therefore, this study aimed to investigate the effect of selenium supplementation on an in vitro model of GDM and maternal obesity. Human placental tissue, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were stimulated with either the bacterial product lipopolysaccharide (LPS) or the pro-inflammatory cytokine TNF-alpha. Selenium pre-treatment blocked LPS and TNF-alpha induced mRNA expression and secretion of pro-inflammatory cytokines and chemokines, while increasing anti-inflammatory cytokine and antioxidant mRNA expression in placenta, VAT and SAT. Selenium pre-treatment was also found to inhibit LPS- and TNF-alpha induced phosphorylation of ERK in placenta, VAT and SAT. These findings indicate that selenium may be able to prevent inflammation and oxidative stress associated with GDM and maternal obesity. Additional in vivo studies are required to identify the efficacy of selenium supplementation in preventing inflammatory pathways activated by GDM and maternal obesity and to elucidate the mechanism involved.
Details
- Title
- Selenium Prevents Inflammation in Human Placenta and Adipose Tissue In Vitro: Implications for Metabolic Diseases of Pregnancy Associated with Inflammation
- Authors
- Caitlyn Nguyen-Ngo (Author) - The University of MelbourneAnthony V. Perkins (Corresponding Author) - Griffith UniversityMartha Lappas (Author) - The University of Melbourne
- Publication details
- Nutrients, Vol.14(16), pp.1-19
- Publisher
- MDPI AG
- Date published
- 2022
- DOI
- 10.3390/nu14163286
- ISSN
- 2072-6643
- PMID
- 36014792
- Copyright note
- Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Grant note
- Department of Obstetrics and Gynaecology, University of Melbourne
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685298902621
- Output Type
- Journal article
Metrics
182 File views/ downloads
29 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Nutrition & Dietetics
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites