Journal article
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
Nature, Vol.534(7608), pp.494-499
2016
Abstract
Voltage-gated sodium (Na v) channels initiate action potentials in most neurons, including primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non-specific actions at all Na v channels, but the discovery of selective modulators would facilitate the analysis of individual subtypes of these channels and their contributions to chemical, mechanical, or thermal pain. Here we identify and characterize spider (Heteroscodra maculata) toxins that selectively activate the Na v 1.1 subtype, the role of which in nociception and pain has not been elucidated. We use these probes to show that Na v 1.1-expressing fibres are modality-specific nociceptors: their activation elicits robust pain behaviours without neurogenic inflammation and produces profound hypersensitivity to mechanical, but not thermal, stimuli. In the gut, high-threshold mechanosensitive fibres also express Na v 1.1 and show enhanced toxin sensitivity in a mouse model of irritable bowel syndrome. Together, these findings establish an unexpected role for Na v 1.1 channels in regulating the excitability of sensory nerve fibres that mediate mechanical pain.
Details
- Title
- Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
- Authors
- J D Osteen (Author)Volker Herzig (Author) - University of QueenslandJ Gilchrist (Author)J J Emrick (Author)C Zhang (Author)X Wang (Author)J Castro (Author)S Garcia-Caraballo (Author)L Grundy (Author)G Y Rychkov (Author)A D Weyer (Author)Z Dekan (Author)E A B Undheim (Author)P Alewood (Author)C L Stucky (Author)S M Brierley (Author)A I Basbaum (Author)F Bosmans (Author)G F King (Author)D Julius (Author)
- Publication details
- Nature, Vol.534(7608), pp.494-499
- Publisher
- Nature Publishing Group
- Date published
- 2016
- DOI
- 10.1038/nature17976
- ISSN
- 0028-0836
- Copyright note
- Copyright © 2016 Nature Publishing Group. The accepted version is reproduced here in accordance with the publishers copyright policy. The definitive version is available from http://dx.doi.org/10.1038/nature17976
- Organisation Unit
- School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451329402621
- Output Type
- Journal article
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