Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats

S A Kumar; M Magnusson; L C Ward; Nicholas A Paul; L Brown

doi:10.3390/md13020788

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Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats

Journal article

Open access

Peer reviewed

Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats

S A Kumar, M Magnusson, L C Ward, Nicholas A Paul and L Brown

Marine Drugs, Vol.13(2), pp.788-805

2015

DOI: https://doi.org/10.3390/md13020788

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Abstract

obesity

hypertension

fatty liver

tropical seaweeds

soluble fibre

Increased seaweed consumption may be linked to the lower incidence of metabolic syndrome in eastern Asia. This study investigated the responses to two tropical green seaweeds, Ulva ohnoi (UO) and Derbesia tenuissima (DT), in a rat model of human metabolic syndrome. Male Wistar rats (330-340 g) were fed either a corn starch-rich diet or a high-carbohydrate, high-fat diet with 25% fructose in drinking water, for 16 weeks. High-carbohydrate, high-fat diet-fed rats showed the signs of metabolic syndrome leading to abdominal obesity, cardiovascular remodelling and non-alcoholic fatty liver disease. Food was supplemented with 5% dried UO or DT for the final 8 weeks only. UO lowered total final body fat mass by 24%, systolic blood pressure by 29 mmHg, and improved glucose utilisation and insulin sensitivity. In contrast, DT did not change total body fat mass but decreased plasma triglycerides by 38% and total cholesterol by 17%. UO contained 18.1% soluble fibre as part of 40.9% total fibre, and increased magnesium, while DT contained 23.4% total fibre, essentially as insoluble fibre. UO was more effective in reducing metabolic syndrome than DT, possibly due to the increased intake of soluble fibre and magnesium. © 2015 by the authors; licensee MDPI, Basel, Switzerland.

Details

Title: Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats
Authors: S A Kumar (Author) - University of Southern Queensland
M Magnusson (Author) - James Cook University
L C Ward (Author) - University of Queensland
Nicholas A Paul (Author) - James Cook University
L Brown (Author) - University of Southern Queensland
Publication details: Marine Drugs, Vol.13(2), pp.788-805
Publisher: MDPI AG
Date published: 2015
DOI: 10.3390/md13020788
ISSN: 1660-3397
Copyright note: Copyright © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/)
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering
Language: English
Record Identifier: 99451072202621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Chemistry, Medicinal; Pharmacology & Pharmacy

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