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Schizophrenia polygenic risk scores in youth mental health- preliminary associations with diagnosis, clinical stage and functioning612.88 kB
Published VersionCC BY V4.0, Open Access
Journal article
Schizophrenia polygenic risk scores in youth mental health: preliminary associations with diagnosis, clinical stage and functioning
BJPsych Open, Vol.7(2), pp.1-9
2021
PMCID: PMC8058892
PMID: 33612137
Appears in Thompson Institute Research Collection
Abstract
The schizophrenia polygenic risk score (SCZ-PRS) is an emerging tool in psychiatry. We aimed to evaluate the utility of SCZ-PRS in a young, transdiagnostic, clinical cohort. SCZ-PRSs were calculated for young people who presented to early-intervention youth mental health clinics, including 158 patients of European ancestry, 113 of whom had longitudinal outcome data. We examined associations between SCZ-PRS and diagnosis, clinical stage and functioning at initial assessment, and new-onset psychotic disorder, clinical stage transition and functional course over time in contact with services. Compared with a control group, patients had elevated PRSs for schizophrenia, bipolar disorder and depression, but not for any non-psychiatric phenotype (for example cardiovascular disease). Higher SCZ-PRSs were elevated in participants with psychotic, bipolar, depressive, anxiety and other disorders. At initial assessment, overall SCZ-PRSs were associated with psychotic disorder (odds ratio (OR) per s.d. increase in SCZ-PRS was 1.68, 95% CI 1.08-2.59, P = 0.020), but not assignment as clinical stage 2+ (i.e. discrete, persistent or recurrent disorder) (OR = 0.90, 95% CI 0.64-1.26, P = 0.53) or functioning (R = 0.03, P = 0.76). Longitudinally, overall SCZ-PRSs were not significantly associated with new-onset psychotic disorder (OR = 0.84, 95% CI 0.34-2.03, P = 0.69), clinical stage transition (OR = 1.02, 95% CI 0.70-1.48, P = 0.92) or persistent functional impairment (OR = 0.84, 95% CI 0.52-1.38, P = 0.50). In this preliminary study, SCZ-PRSs were associated with psychotic disorder at initial assessment in a young, transdiagnostic, clinical cohort accessing early-intervention services. Larger clinical studies are needed to further evaluate the clinical utility of SCZ-PRSs, especially among individuals with high SCZ-PRS burden.
Details
- Title
- Schizophrenia polygenic risk scores in youth mental health: preliminary associations with diagnosis, clinical stage and functioning
- Authors
- Jacob J Crouse (Corresponding Author) - The University of SydneyJoanne S Carpenter (Author) - The University of SydneyFrank Iorfino (Author) - The University of SydneyTian Lin (Author) - The University of QueenslandNicholas Ho (Author) - The University of SydneyEnda M Byrne (Author) - The University of QueenslandAnjali K Henders (Author) - The University of QueenslandLeanne Wallace (Author) - The University of QueenslandDaniel F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteElizabeth M Scott (Author) - The University of SydneyNaomi R Wray (Author) - The University of QueenslandIan B Hickie (Author) - The University of Sydney
- Publication details
- BJPsych Open, Vol.7(2), pp.1-9
- Publisher
- Cambridge University Press
- Date published
- 2021
- DOI
- 10.1192/bjo.2021.14
- ISSN
- 2056-4724
- PMID
- 33612137; PMC8058892
- Copyright note
- Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99511207402621
- Output Type
- Journal article
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