Scabies mite inactivated protease paralogues

K Fischer; D C Holt; B J Currie; Shelley F Walton; D J Kemp

doi:10.1016/j.ics.2005.10.030

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Scabies mite inactivated protease paralogues

Journal article

Peer reviewed

Scabies mite inactivated protease paralogues

K Fischer, D C Holt, B J Currie, Shelley F Walton and D J Kemp

International Congress Series, Vol.1289, pp.85-88

Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD), XVIth (Palm Cove, Australia, 25-Sep-2005–29-Sep-2005)

2006

DOI: https://doi.org/10.1016/j.ics.2005.10.030

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Abstract

Medical Microbiology

inactivated serine protease

inactivated cysteine protease

Scabies is a disease of considerable importance in the developing world and among disadvantaged people such as the Aborigines in Australia, as it underlies streptococcal skin infections. It has been neglected at the molecular level until very recently. However, 43,776 expressed sequence tags have now been generated at the Australian Genome Research Facility from a cDNA library we constructed. Unexpectedly, in a search for homologues of house dust mite allergens among these sequences, we discovered large families of serine and cysteine protease genes with genetically inactivated catalytic sites. These are strong candidates for parasite defences against host immunity as we did not find them in a house dust mite cDNA library. Some possible modes of action are discussed.

Details

Title: Scabies mite inactivated protease paralogues
Authors: K Fischer (Author) - University of Queensland
D C Holt (Author) - Charles Darwin University
B J Currie (Author) - Charles Darwin University
Shelley F Walton (Author) - Charles Darwin University
D J Kemp (Author) - University of Queensland
Contributors: K S Sriprakash (Editor)
Publication details: International Congress Series, Vol.1289, pp.85-88
Conference details: Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD), XVIth (Palm Cove, Australia, 25-Sep-2005–29-Sep-2005)
Publisher: Elsevier BV
Date published: 2006
DOI: 10.1016/j.ics.2005.10.030
ISSN: 0531-5131
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99449988702621
Output Type: Journal article

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