Scabies Mite Inactivated Serine Protease Paralogues are Present Both Internally in the Mite Gut and Externally in Feces

C Willis; K Fischer; Shelley F Walton; B J Currie; D J Kemp

doi:10.4269/ajtmh.2006.75.683

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Scabies Mite Inactivated Serine Protease Paralogues are Present Both Internally in the Mite Gut and Externally in Feces

Journal article

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Scabies Mite Inactivated Serine Protease Paralogues are Present Both Internally in the Mite Gut and Externally in Feces

C Willis, K Fischer, Shelley F Walton, B J Currie and D J Kemp

American Journal of Tropical Medicine and Hygiene, Vol.75(4), pp.683-687

2006

DOI: https://doi.org/10.4269/ajtmh.2006.75.683

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Abstract

Medical Microbiology

Sarcoptes scabiei

scabies mite inactivated protease paralogues [SMIPPs]

The scabies mite, Sarcoptes scabiei, is the causative agent of scabies, a disease that is common among disadvantaged populations and facilitates streptococcal infections with serious sequelae. Previously, we encountered large families of genes encoding paralogues of house dust mite protease allergens with their catalytic sites inactivated by mutation (scabies mite inactivated protease paralogues [SMIPPs]). We postulated that SMIPPs have evolved as an adaptation to the parasitic lifestyle of the scabies mite, functioning as competitive inhibitors of proteases involved in the host-parasite interaction. To propose testable hypotheses for their functions, it is essential to know their locations in the mite. Here we show by immunohistochemistry that SMIPPs exist in two compartments: 1) internal to the mite in the gut and 2) external to the mite after excretion from the gut in scybala (fecal pellets). SMIPPs may well function in both of these compartments to evade host proteases.

Details

Title: Scabies Mite Inactivated Serine Protease Paralogues are Present Both Internally in the Mite Gut and Externally in Feces
Authors: C Willis (Author) - University of Queensland
K Fischer (Author) - University of Queensland
Shelley F Walton (Author) - Charles Darwin University
B J Currie (Author) - University of Queensland
D J Kemp (Author) - University of Queensland
Publication details: American Journal of Tropical Medicine and Hygiene, Vol.75(4), pp.683-687
Publisher: American Society of Tropical Medicine and Hygiene
Date published: 2006
DOI: 10.4269/ajtmh.2006.75.683
ISSN: 0002-9637
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99449699802621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Public, Environmental & Occupational Health; Tropical Medicine

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