SMAD expression in the testis: An insight into BMP regulation of spermatogenesis

Catherine Itman; K L Loveland

doi:10.1002/dvdy.21401

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SMAD expression in the testis: An insight into BMP regulation of spermatogenesis

Journal article

Peer reviewed

SMAD expression in the testis: An insight into BMP regulation of spermatogenesis

Catherine Itman and K L Loveland

Developmental Dynamics, Vol.237(1), pp.97-111

2008

DOI: https://doi.org/10.1002/dvdy.21401

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Abstract

SMADs

testis

spermatogenesis

BMP

expression

Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β superfamily, extensively influence events that establish male fertility, affecting germ cells and somatic cells throughout fetal and postnatal life. BMP signals are relayed by SMAD proteins, transcription factors that translocate to the nucleus upon ligand stimulation. We show that BMP signaling in the testis may be regulated by selective expression of BMP-responsive and inhibitory SMADs, with expression differing between the first wave and adult spermatogenesis. Smad1, Smad5, Smad8, Smad4, Smad6, and Smad7 expression is ubiquitous during testis development but becomes cell-specific in the adult. Furthermore, regulated SMAD6 protein expression at the onset of spermatogenesis suggests differential responsiveness of sperm at ogonial subpopulations to ligands. In vitro, immature Sertoli cells and spermatogonia transduce BMP2 and BMP4 signals by means of SMAD1, SMAD5, and SMAD8. Based on these findings, we extrapolate these data to interpret BMP mutant testis phenotypes in terms of SMAD availability for signal transduction. © 2007 Wiley-Liss, Inc.

Details

Title: SMAD expression in the testis: An insight into BMP regulation of spermatogenesis
Authors: Catherine Itman (Author) - Monash University
K L Loveland (Author) - Monash University
Publication details: Developmental Dynamics, Vol.237(1), pp.97-111
Publisher: John Wiley & Sons Inc.
Date published: 2008
DOI: 10.1002/dvdy.21401
ISSN: 1058-8388
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449580502621
Output Type: Journal article

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