Journal article
Role of omega-6 and omega-3 fatty acids in fetal programming
Clinical and Experimental Pharmacology & Physiology, Vol.47(5), pp.907-915
2020
PMID: 31883131
Abstract
Maternal nutrition plays a critical role in fetal development and can influence adult onset of disease. Linoleic acid (LA) and alpha-linolenic acid (ALA) are major omega-6 (n-6) and n-3 polyunsaturated fatty acids (PUFA), respectively, that are essential in our diet. LA and ALA are critical for the development of the fetal neurological and immune systems. However, in recent years, the consumption of n-6 PUFA has increased gradually worldwide, and elevated n-6 PUFA consumption may be harmful to human health. Consumption of diets with high levels of n-6 PUFA before or during pregnancy may have detrimental effects on fetal development and may influence overall health of offspring in adulthood. This review discusses the role of n-6 PUFA in fetal programming, the importance of a balance between n-6 and n-3 PUFAs in the maternal diet, and the need of further animal models and human studies that critically evaluate both n-6 and n-3 PUFA contents in diets.
Details
- Title
- Role of omega-6 and omega-3 fatty acids in fetal programming
- Authors
- Nirajan Shrestha (Author) - Griffith UniversitySimone L. Sleep (Author) - Griffith UniversityJames S. M. Cuffe (Author) - Griffith UniversityOlivia J. Holland (Author) - Griffith UniversityAnthony V. Perkins (Author) - Griffith UniversitySuk Yu Yau (Author) - Hong Kong Polytechnic UniversityAndrew J. McAinch (Author) - Victoria UniversityDeanne H. Hryciw (Corresponding Author) - Victoria University
- Publication details
- Clinical and Experimental Pharmacology & Physiology, Vol.47(5), pp.907-915
- Publisher
- John Wiley & Sons, Inc.
- Date published
- 2020
- DOI
- 10.1111/1440-1681.13244
- ISSN
- 1440-1681; 0305-1870
- PMID
- 31883131
- Copyright note
- © 2019 The Authors and Blackwell Publishing Asia Pty Ltd. This is the peer reviewed version of the following article: Role OfOmega-6 and Omega-3 fatty acids in fetal programming, Clinical and Experimental Pharmacology and Physiology, 2019, which has been published in final form at https://doi.org/10.1111/1440-1681.13244. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99685196502621
- Output Type
- Journal article
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