Risk of second primary cancer in survivors of in situ melanoma

Michael G Kimlin; D R Youlden; Alison M Brodie; Tracey Di Sipio; Philippa H Youl; V Nair-Shalliker; P D Baade

doi:10.1016/j.jid.2018.11.001

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Risk of second primary cancer in survivors of in situ melanoma

Journal article

Peer reviewed

Risk of second primary cancer in survivors of in situ melanoma

Michael G Kimlin, D R Youlden, Alison M Brodie, Tracey Di Sipio, Philippa H Youl, V Nair-Shalliker and P D Baade

Journal of Investigative Dermatology, Vol.139(4), pp.842-847

2019

DOI: https://doi.org/10.1016/j.jid.2018.11.001

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Abstract

Invasive melanoma survivors have an increased risk of developing second primary cancers, however, similar risks associated with in situ melanoma haven't been established. We evaluated 43,829 first primary in situ melanoma survivors diagnosed from 1982-2012 in Queensland, Australia. Risk of second non-melanoma primary cancers was estimated from standardized incidence ratios with 95% confidence intervals. A total of 4,917 (11.3%) in situ melanoma survivors developed a second primary cancer. No net increased risk compared with the general population was found. In those aged <50 years, risk was increased by 13% for all cancers combined. In situ melanoma survivors had significantly increased risks of developing lip, brain, and thyroid cancers, and decreased risks of head and neck, lung, bladder, and colorectal cancers. Male in situ melanoma survivors had a significantly increased risk of prostate cancer; female survivors had an increased risk of thyroid cancer and lymphoid leukaemia, and a decreased risk of gynaecological cancers. Findings indicate in situ melanoma may predict the diagnosis of certain second primary cancers. This altered risk may be due to biological, behavioural or genetic factors, or increased medical surveillance, and requires further investigation, particularly among people aged under 50 years.

Details

Title: Risk of second primary cancer in survivors of in situ melanoma
Authors: Michael G Kimlin (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
D R Youlden (Author) - Griffith University
Alison M Brodie (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Tracey Di Sipio (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Philippa H Youl (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
V Nair-Shalliker (Author) - Cancer Council New South Wales (CCNSW)
P D Baade (Author) - Griffith University
Publication details: Journal of Investigative Dermatology, Vol.139(4), pp.842-847
Publisher: Nature Publishing Group
Date published: 2019
DOI: 10.1016/j.jid.2018.11.001
ISSN: 0022-202X
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450786302621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Dermatology

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