Ricicomin A, a new alkaloid from the leaves of Ricinus communis Linn

Nguyen Kim Tuyen Pham; Thi Thao Linh Tran; Thuc Huy Duong; Nguyen Tien Trung; Dang Cam Tu  Phan; Dinh Tri Mai; Van Kiew Nguyen; Bui Linh Chi Huynh; Thi Anh Tuyet Nguyen; Trong Tran; Thi Ngoc Mai  Tran; Tan Phat Nguyen

doi:10.1080/14786419.2020.1839456

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Ricicomin A, a new alkaloid from the leaves of Ricinus communis Linn

Journal article

Peer reviewed

Ricicomin A, a new alkaloid from the leaves of Ricinus communis Linn

Nguyen Kim Tuyen Pham, Thi Thao Linh Tran, Thuc Huy Duong, Nguyen Tien Trung, Dang Cam Tu Phan, Dinh Tri Mai, Van Kiew Nguyen, Bui Linh Chi Huynh, Thi Anh Tuyet Nguyen, Trong Tran, …

Natural Product Research, Vol.36(8), pp.1973-1979

2022

DOI: https://doi.org/10.1080/14786419.2020.1839456

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Abstract

Ricinus communis

Euphorbiaceae

alkaloid

ricicomin A

From the leaves of Ricinus communis Linn., one new alkaloid, named ricicomin A (1) together with three known ones, ricinine (2), N-demethylricinine (3) and 4-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoic acid (4) were justified by repeated chromatographic methods. Their structures were determined by comprehensive IR, HR-ESI-MS and NMR analyses. Compound 4 was identified for the first time from the genus Ricinus. DFT-NMR chemical shift calculations and subsequent DP4+ probability methods were applied to confirm the chemical structure of 1. Compounds 1–3 did not display cytotoxic effect against three human cancer cell lines (MCF-7, HepG2 and HeLa) using SRB assay.

Details

Title: Ricicomin A, a new alkaloid from the leaves of Ricinus communis Linn
Authors: Nguyen Kim Tuyen Pham (Author) - Saigon University
Thi Thao Linh Tran (Author) - Saigon University
Thuc Huy Duong (Author) - Ho Chi Minh City Pedagogical University
Nguyen Tien Trung (Author) - Quy Nhon University
Dang Cam Tu Phan (Author) - Quy Nhon University
Dinh Tri Mai (Author) - Vietnam Academy of Science and Technology
Van Kiew Nguyen (Author) - Duy Tan University
Bui Linh Chi Huynh (Author) - Dong Nai University (Vietnam)
Thi Anh Tuyet Nguyen (Author) - Ho Chi Minh City Pedagogical University
Trong Tran (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Thi Ngoc Mai Tran (Author) - Ho Chi Minh City University of Technology
Tan Phat Nguyen (Author) - Vietnam Academy of Science and Technology
Publication details: Natural Product Research, Vol.36(8), pp.1973-1979
Publisher: Taylor & Francis
DOI: 10.1080/14786419.2020.1839456
ISSN: 1478-6427
Organisation Unit: Centre for Bioinnovation; School of Science and Engineering - Legacy; School of Science, Technology and Engineering; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99482287102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Chemistry, Applied; Chemistry, Medicinal

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