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Published VersionCC BY V4.0, Open Access
Journal article
Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation
Frontiers in Oncology, Vol.10, pp.1-10
2020
PMID: 33224887
Abstract
Once thought to be exclusively a storage hub for glucose, glycogen is now known to be essential in a range of physiological processes and pathological conditions. Glycogen lies at the nexus of diverse processes that promote malignancy, including proliferation, migration, invasion, and chemoresistance of cancer cells. It is also implicated in processes associated with the tumor microenvironment such as immune cell effector function and crosstalk with cancer-associated fibroblasts to promote metastasis. The enzymes of glycogen metabolism are dysregulated in a wide variety of malignancies, including cancers of the kidney, ovary, lung, bladder, liver, blood, and breast. Understanding and targeting glycogen metabolism in cancer presents a promising but under-explored therapeutic avenue. In this review, we summarize the current literature on the role of glycogen in cancer progression and discuss its potential as a therapeutic target for cancer treatment.
Details
- Title
- Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation
- Authors
- Tashbib Khan - Translational Research InstituteMitchell A Sullivan - Translational Research InstituteJennifer H Gunter - Queensland University of TechnologyNicholas Lyons - Translational Research InstituteJohn D Hooper (Corresponding Author) - Translational Research Institute
- Publication details
- Frontiers in Oncology, Vol.10, pp.1-10
- Publisher
- Frontiers Research Foundation
- Date published
- 2020
- DOI
- 10.3389/fonc.2020.592455
- ISSN
- 2234-943X
- PMID
- 33224887
- Copyright note
- © 2020 Khan, Sullivan, Gunter, Kryza, Lyons, He and Hooper. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Grant note
- This study was supported by a grant from the Australia New Zealand Gynecological Oncology Group and philanthropic support from the Mater Foundation (JH) and a higher degree scholarship awarded by The University of Queensland Graduate School (TKh). MS is supported by a Mater Foundation McGuckin Early Career Fellowship and the University of Queensland Amplify Initiative.
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035095202621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Oncology
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Source: InCites