Journal article
Review: Placental mitochondrial function and structure in gestational disorders
Placenta, Vol.54, pp.2-9
2017
PMID: 28024805
Abstract
The aetiology of many gestational disorders is still unknown. However, insufficient trans-placental nutrient and oxygen transfer due to abnormal placentation is characteristic of several pathologies, and may alter the function of placental mitochondria. Mitochondria are multifunctional organelles that respond to a wide range of stimuli – such as physiological changes in cellular energy demands or various pathologies – by reshaping via fusion or fission, increasing/decreasing in number, altering oxidative phosphorylation, and signalling cellular functions such as apoptosis. Mitochondrial function is integral to tissue functions including energy production, metabolism, and regulation of various cellular responses including response to oxidative stress. This review details the functions of placental mitochondria and investigates mitochondrial function and structure in gestational disorders including preeclampsia, intrauterine growth restriction, diabetes mellitus, and obesity. Placental mitochondrial dysfunction may be critical in a range of gestational disorders which have important implications for maternal and fetal/offspring health.
Details
- Title
- Review: Placental mitochondrial function and structure in gestational disorders
- Authors
- Olivia Holland (Author) - Griffith UniversityMarloes Dekker Nitert (Author) - University of QueenslandLinda A Gallo (Author) - University of QueenslandMeliha Vejzovic (Author) - Griffith UniversityJoshua J Fisher (Author) - School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast Campus Southport, Queensland, AustraliaAnthony V Perkins (Author) - Griffith University
- Publication details
- Placenta, Vol.54, pp.2-9
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.placenta.2016.12.012
- ISSN
- 1532-3102
- PMID
- 28024805
- Organisation Unit
- School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99620506402621
- Output Type
- Journal article
Metrics
30 Record Views
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Developmental Biology
- Obstetrics & Gynecology
- Reproductive Biology
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Source: InCites