Logo image
Reversal of the anti-ovulatory action of stress in rats by prior administration of naloxone hydrochloride
Journal article   Peer reviewed

Reversal of the anti-ovulatory action of stress in rats by prior administration of naloxone hydrochloride

G Hulse, G Coleman, J Nicholas and Ken Greenwood
Journal of Reproduction and Fertility, Vol.66(2), pp.451-456
1982
url
https://doi.org/10.1530/jrf.0.0660451View
Published Version

Abstract

Immature, 32-day-old rats were treated with PMSG. Stress consisting of 180 min immobilization administered during the period of the preovulatory LH surge resulted in the blockage of ovulation. The anti-ovulatory action of stress was effectively antagonized by the administration of naloxone hydrochloride shortly before the application of the stress, suggesting that the ovulation block by stress is mediated by endogenous opioids known to be elevated during stress. Blockage of ovulation by 180 min immobilization stress occurred only in rats from one of the two laboratory strains tested, suggesting that stress resistance is, at least in part, genetically determined.

Details

Metrics

386 Record Views
Logo image